Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model
PURPOSE: To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats. METHODS: Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty ac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2014-01-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001300009&tlng=en |
| _version_ | 1818492305636589568 |
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| author | Jorge Luiz Medeiros Júnior Fabiana Araújo de Oliveira Pamella Campos Silva Angélica Furriel Francisco José Barcellos Sampaio Bianca Martins Gregório |
| author_facet | Jorge Luiz Medeiros Júnior Fabiana Araújo de Oliveira Pamella Campos Silva Angélica Furriel Francisco José Barcellos Sampaio Bianca Martins Gregório |
| author_sort | Jorge Luiz Medeiros Júnior |
| collection | DOAJ |
| description | PURPOSE: To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats. METHODS: Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis. RESULTS: All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003). CONCLUSION: Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction. |
| first_indexed | 2024-12-10T17:41:17Z |
| format | Article |
| id | doaj.art-4c249626c5934d44b653f44eb5816be5 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-10T17:41:17Z |
| publishDate | 2014-01-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-4c249626c5934d44b653f44eb5816be52022-12-22T01:39:22ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502014-01-0129suppl 1394410.1590/S0102-86502014001300008Lard and/or canola oil-rich diets induce penile morphological alterations in a rat modelJorge Luiz Medeiros JúniorFabiana Araújo de OliveiraPamella Campos SilvaAngélica FurrielFrancisco José Barcellos SampaioBianca Martins GregórioPURPOSE: To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats. METHODS: Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis. RESULTS: All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003). CONCLUSION: Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001300009&tlng=enCanola oilHigh-fat dietLardMorphologyPenisRats |
| spellingShingle | Jorge Luiz Medeiros Júnior Fabiana Araújo de Oliveira Pamella Campos Silva Angélica Furriel Francisco José Barcellos Sampaio Bianca Martins Gregório Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model Acta Cirúrgica Brasileira Canola oil High-fat diet Lard Morphology Penis Rats |
| title | Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model |
| title_full | Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model |
| title_fullStr | Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model |
| title_full_unstemmed | Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model |
| title_short | Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model |
| title_sort | lard and or canola oil rich diets induce penile morphological alterations in a rat model |
| topic | Canola oil High-fat diet Lard Morphology Penis Rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001300009&tlng=en |
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