Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow
Abstract. Background:. The effect of arteriosclerotic intracranial arterial vessel wall enhancement (IAVWE) on downstream collateral flow found in vessel wall imaging (VWI) is not clear. Regardless of the mechanism underlying IAVWE on VWI, damage to the patient's nervous system caused by IAVWE...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-09-01
|
| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002307 |
| _version_ | 1797677006212562944 |
|---|---|
| author | Liqun Yan Jin Yan Zhenchang Wang Guoshi Wang Zhenzhong Li Yaping Hou Boyuan Huang Qianbo Dong Xiaodan Mu Wei Cao Pengfei Zhao Yanjie Yin |
| author_facet | Liqun Yan Jin Yan Zhenchang Wang Guoshi Wang Zhenzhong Li Yaping Hou Boyuan Huang Qianbo Dong Xiaodan Mu Wei Cao Pengfei Zhao Yanjie Yin |
| author_sort | Liqun Yan |
| collection | DOAJ |
| description | Abstract.
Background:. The effect of arteriosclerotic intracranial arterial vessel wall enhancement (IAVWE) on downstream collateral flow found in vessel wall imaging (VWI) is not clear. Regardless of the mechanism underlying IAVWE on VWI, damage to the patient's nervous system caused by IAVWE is likely achieved by affecting downstream cerebral blood flow. The present study aimed to investigate the effect of arteriosclerotic IAVWE on downstream collateral flow.
Methods:. The present study recruited 63 consecutive patients at the Second Hospital of Hebei Medical University from January 2021 to November 2021 with underlying atherosclerotic diseases and unilateral middle cerebral artery (MCA) M1-segment stenosis who underwent an magnetic resonance scan within 3 days of symptom onset. The patients were divided into 4 groups according to IAVWE and the stenosis ratio (Group 1, n = 17; Group 2, n = 19; Group 3, n = 13; Group 4, n = 14), and downstream collateral flow was analyzed using three-dimensional pseudocontinuous arterial spin labeling (3D-pCASL) and RAPID software. The National Institutes of Health Stroke Scale (NIHSS) scores of the patients were also recorded. Two-factor multivariate analysis of variance using Pillai's trace was used as the main statistical method.
Results:. No statistically significant difference was found in baseline demographic characteristics among the groups. IAVWE, but not the stenosis ratio, had a statistically significant significance on the late-arriving retrograde flow proportion (LARFP), hypoperfusion intensity ratio (HIR), and NIHSS scores (F = 20.941, P <0.001, Pillai's trace statistic = 0.567). The between-subject effects test showed that IAVWE had a significant effect on the three dependent variables: LARFP (R2 = 0.088, F = 10.899, P = 0.002), HIR (R2 = 0.234, F = 29.354, P <0.001), and NIHSS (R2 = 114.339, F = 33.338, P <0.001).
Conclusions:. Arteriosclerotic IAVWE significantly reduced downstream collateral flow and affected relevant neurological deficits. It was an independent factor affecting downstream collateral flow and NIHSS scores, which should be a focus of future studies.
Trial Registration:. ChiCTR.org.cn, ChiCTR2100053661 |
| first_indexed | 2024-03-11T22:37:51Z |
| format | Article |
| id | doaj.art-4c258ab8b9b944bc8f9e587eb58d8f76 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-11T22:37:51Z |
| publishDate | 2023-09-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-4c258ab8b9b944bc8f9e587eb58d8f762023-09-22T10:42:41ZengWolters KluwerChinese Medical Journal0366-69992542-56412023-09-01136182221222810.1097/CM9.0000000000002307202309200-00011Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flowLiqun Yan0Jin Yan1Zhenchang Wang2Guoshi Wang3Zhenzhong Li4Yaping Hou5Boyuan Huang6Qianbo Dong7Xiaodan Mu8Wei Cao9Pengfei Zhao10Yanjie Yin1 Department of Radiology, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China3 Department of Clinical Medicine, Tianjin Medical University, Tianjin 300203, China1 Department of Radiology, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China2 Departments of Medical Imaging, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China4 Departments of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China5 Hebei Province Blood Center, Shijiazhuang, Hebei 050000, China.2 Departments of Medical Imaging, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China2 Departments of Medical Imaging, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China2 Departments of Medical Imaging, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China2 Departments of Medical Imaging, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China1 Department of Radiology, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, ChinaAbstract. Background:. The effect of arteriosclerotic intracranial arterial vessel wall enhancement (IAVWE) on downstream collateral flow found in vessel wall imaging (VWI) is not clear. Regardless of the mechanism underlying IAVWE on VWI, damage to the patient's nervous system caused by IAVWE is likely achieved by affecting downstream cerebral blood flow. The present study aimed to investigate the effect of arteriosclerotic IAVWE on downstream collateral flow. Methods:. The present study recruited 63 consecutive patients at the Second Hospital of Hebei Medical University from January 2021 to November 2021 with underlying atherosclerotic diseases and unilateral middle cerebral artery (MCA) M1-segment stenosis who underwent an magnetic resonance scan within 3 days of symptom onset. The patients were divided into 4 groups according to IAVWE and the stenosis ratio (Group 1, n = 17; Group 2, n = 19; Group 3, n = 13; Group 4, n = 14), and downstream collateral flow was analyzed using three-dimensional pseudocontinuous arterial spin labeling (3D-pCASL) and RAPID software. The National Institutes of Health Stroke Scale (NIHSS) scores of the patients were also recorded. Two-factor multivariate analysis of variance using Pillai's trace was used as the main statistical method. Results:. No statistically significant difference was found in baseline demographic characteristics among the groups. IAVWE, but not the stenosis ratio, had a statistically significant significance on the late-arriving retrograde flow proportion (LARFP), hypoperfusion intensity ratio (HIR), and NIHSS scores (F = 20.941, P <0.001, Pillai's trace statistic = 0.567). The between-subject effects test showed that IAVWE had a significant effect on the three dependent variables: LARFP (R2 = 0.088, F = 10.899, P = 0.002), HIR (R2 = 0.234, F = 29.354, P <0.001), and NIHSS (R2 = 114.339, F = 33.338, P <0.001). Conclusions:. Arteriosclerotic IAVWE significantly reduced downstream collateral flow and affected relevant neurological deficits. It was an independent factor affecting downstream collateral flow and NIHSS scores, which should be a focus of future studies. Trial Registration:. ChiCTR.org.cn, ChiCTR2100053661http://journals.lww.com/10.1097/CM9.0000000000002307 |
| spellingShingle | Liqun Yan Jin Yan Zhenchang Wang Guoshi Wang Zhenzhong Li Yaping Hou Boyuan Huang Qianbo Dong Xiaodan Mu Wei Cao Pengfei Zhao Yanjie Yin Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow Chinese Medical Journal |
| title | Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow |
| title_full | Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow |
| title_fullStr | Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow |
| title_full_unstemmed | Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow |
| title_short | Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow |
| title_sort | effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow |
| url | http://journals.lww.com/10.1097/CM9.0000000000002307 |
| work_keys_str_mv | AT liqunyan effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT jinyan effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT zhenchangwang effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT guoshiwang effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT zhenzhongli effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT yapinghou effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT boyuanhuang effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT qianbodong effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT xiaodanmu effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT weicao effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT pengfeizhao effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow AT yanjieyin effectofarterioscleroticintracranialarterialvesselwallenhancementondownstreamcollateralflow |