Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats
Background: The objective of the study was to investigate the protective effects of aqueous extract of Plantago ovata seed (AEPOS) on peptic ulcer induced by indomethacin (IND) in rats. Methods: Rats (250-300 g) were divided into three groups (5 rats in each group). Gastric ulcer was induced by a si...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Biomedical Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417018300155 |
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| author | Seyyed Majid Bagheri Fatemeh Zare-Mohazabieh Haniyeh Momeni-Asl Maryam Yadegari Aghdas Mirjalili Morteza Anvari |
| author_facet | Seyyed Majid Bagheri Fatemeh Zare-Mohazabieh Haniyeh Momeni-Asl Maryam Yadegari Aghdas Mirjalili Morteza Anvari |
| author_sort | Seyyed Majid Bagheri |
| collection | DOAJ |
| description | Background: The objective of the study was to investigate the protective effects of aqueous extract of Plantago ovata seed (AEPOS) on peptic ulcer induced by indomethacin (IND) in rats. Methods: Rats (250-300 g) were divided into three groups (5 rats in each group). Gastric ulcer was induced by a single oral gavage of 48 mg/kg IND. The first group received only 5% sodium bicarbonate orally (5 ml/kg) whereas the control (IND) group received only single oral dose of 48 mg/kg IND. The third group was pretreated with an extract (100 mg/kg) for 4 days. At the end of the 4th day, rats were kept fasted for 24 h before administration of IND 48 mg/kg. The rats were sacrificed 4 h after oral administration of IND and their stomach and liver were fixed in formalin (10%) and sections of 5 mm in diameter were prepared. Histological and morphological characteristics of stomach and liver were assessed using hematoxylin and eosin (H&E) staining. Results: AEPOS (100 mg/kg) showed a significant (p < 0.05) reduction in microscopic and macroscopic ulcer index as compared to the IND group. Histological analysis indicated that AEPOS has hepatoprotective effect and can prevent mucosa damage in stomach. Conclusion: Results revealed that AEPOS has anti-ulcer and hepatoprotective effects. Keywords: Indomethacin, Plantago ovata seed, Hepatotoxicity, Aqueous extract |
| first_indexed | 2024-04-11T13:51:26Z |
| format | Article |
| id | doaj.art-4c260a52d1814f1d895e37cadcf310c9 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-11T13:51:26Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-4c260a52d1814f1d895e37cadcf310c92022-12-22T04:20:33ZengElsevierBiomedical Journal2319-41702018-02-014114145Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated ratsSeyyed Majid Bagheri0Fatemeh Zare-Mohazabieh1Haniyeh Momeni-Asl2Maryam Yadegari3Aghdas Mirjalili4Morteza Anvari5Department of Physiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Corresponding author. Department of Physiology, Shahid Sadoughi University of Medical Sciences, Iran. Prof. Hesabi Bulvd, Shohadaye Gomnam Bulvd, 8915173149, Yazd, Iran.School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranSchool of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Anatomy, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Anatomy, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Anatomy, Shahid Sadoughi University of Medical Sciences, Yazd, IranBackground: The objective of the study was to investigate the protective effects of aqueous extract of Plantago ovata seed (AEPOS) on peptic ulcer induced by indomethacin (IND) in rats. Methods: Rats (250-300 g) were divided into three groups (5 rats in each group). Gastric ulcer was induced by a single oral gavage of 48 mg/kg IND. The first group received only 5% sodium bicarbonate orally (5 ml/kg) whereas the control (IND) group received only single oral dose of 48 mg/kg IND. The third group was pretreated with an extract (100 mg/kg) for 4 days. At the end of the 4th day, rats were kept fasted for 24 h before administration of IND 48 mg/kg. The rats were sacrificed 4 h after oral administration of IND and their stomach and liver were fixed in formalin (10%) and sections of 5 mm in diameter were prepared. Histological and morphological characteristics of stomach and liver were assessed using hematoxylin and eosin (H&E) staining. Results: AEPOS (100 mg/kg) showed a significant (p < 0.05) reduction in microscopic and macroscopic ulcer index as compared to the IND group. Histological analysis indicated that AEPOS has hepatoprotective effect and can prevent mucosa damage in stomach. Conclusion: Results revealed that AEPOS has anti-ulcer and hepatoprotective effects. Keywords: Indomethacin, Plantago ovata seed, Hepatotoxicity, Aqueous extracthttp://www.sciencedirect.com/science/article/pii/S2319417018300155 |
| spellingShingle | Seyyed Majid Bagheri Fatemeh Zare-Mohazabieh Haniyeh Momeni-Asl Maryam Yadegari Aghdas Mirjalili Morteza Anvari Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats Biomedical Journal |
| title | Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats |
| title_full | Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats |
| title_fullStr | Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats |
| title_full_unstemmed | Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats |
| title_short | Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats |
| title_sort | antiulcer and hepatoprotective effects of aqueous extract of plantago ovata seed on indomethacin ulcerated rats |
| url | http://www.sciencedirect.com/science/article/pii/S2319417018300155 |
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