Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone
Brown tumors (BTs) are expansile osteolytic lesions complicating severe primary hyperparathyroidism (PHPT). Clinical, radiological and histological features of BTs share many similarities with other giant cell-containing lesions of the bone, which can make their diagnosis challenging. We report the...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2020-04-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0029.xml |
| _version_ | 1811223982252228608 |
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| author | S Hamidi S Mottard M J Berthiaume J Doyon M J Bégin L Bondaz |
| author_facet | S Hamidi S Mottard M J Berthiaume J Doyon M J Bégin L Bondaz |
| author_sort | S Hamidi |
| collection | DOAJ |
| description | Brown tumors (BTs) are expansile osteolytic lesions complicating severe primary hyperparathyroidism (PHPT). Clinical, radiological and histological features of BTs share many similarities with other giant cell-containing lesions of the bone, which can make their diagnosis challenging. We report the case of a 32-year-old man in whom an aggressive osteolytic lesion of the iliac crest was initially diagnosed as a giant cell tumor by biopsy. The patient was scheduled for surgical curettage, with a course of neoadjuvant denosumab. Routine biochemical workup prior to denosumab administration incidentally revealed high serum calcium levels. The patient was diagnosed with PHPT and a parathyroid adenoma was identified. In light of these findings, histological slices of the iliac lesion were reviewed and diagnosis of a BT was confirmed. Follow-up CT-scans performed 2 and 7 months after parathyroidectomy showed regression and re-ossification of the bone lesion. The aim of this case report is to underline the importance of distinguishing BTs from other giant cell-containing lesions of the bone and to highlight the relevance of measuring serum calcium as part of the initial evaluation of osteolytic bone lesions. This can have a major impact on patients’ management and can prevent unnecessary invasive surgical interventions. |
| first_indexed | 2024-04-12T08:41:35Z |
| format | Article |
| id | doaj.art-4c2624b2487d44e781cc8317c9e4bbf0 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 2052-0573 |
| language | English |
| last_indexed | 2024-04-12T08:41:35Z |
| publishDate | 2020-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-4c2624b2487d44e781cc8317c9e4bbf02022-12-22T03:39:50ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732020-04-01111610.1530/EDM-20-0029Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the boneS Hamidi0S Mottard1M J Berthiaume2J Doyon3M J Bégin4L Bondaz5Division of Endocrinology, Department of MedicineDivision of Orthopedic Surgery, Department of SurgeryDepartment of RadiologyDepartment of Pathology, Hôpital Maisonneuve-Rosemont, Montréal, CanadaDivision of Endocrinology, Department of MedicineDivision of Endocrinology, Department of MedicineBrown tumors (BTs) are expansile osteolytic lesions complicating severe primary hyperparathyroidism (PHPT). Clinical, radiological and histological features of BTs share many similarities with other giant cell-containing lesions of the bone, which can make their diagnosis challenging. We report the case of a 32-year-old man in whom an aggressive osteolytic lesion of the iliac crest was initially diagnosed as a giant cell tumor by biopsy. The patient was scheduled for surgical curettage, with a course of neoadjuvant denosumab. Routine biochemical workup prior to denosumab administration incidentally revealed high serum calcium levels. The patient was diagnosed with PHPT and a parathyroid adenoma was identified. In light of these findings, histological slices of the iliac lesion were reviewed and diagnosis of a BT was confirmed. Follow-up CT-scans performed 2 and 7 months after parathyroidectomy showed regression and re-ossification of the bone lesion. The aim of this case report is to underline the importance of distinguishing BTs from other giant cell-containing lesions of the bone and to highlight the relevance of measuring serum calcium as part of the initial evaluation of osteolytic bone lesions. This can have a major impact on patients’ management and can prevent unnecessary invasive surgical interventions.https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0029.xml |
| spellingShingle | S Hamidi S Mottard M J Berthiaume J Doyon M J Bégin L Bondaz Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone Endocrinology, Diabetes & Metabolism Case Reports |
| title | Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone |
| title_full | Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone |
| title_fullStr | Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone |
| title_full_unstemmed | Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone |
| title_short | Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone |
| title_sort | brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone |
| url | https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0029.xml |
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