Biological Scaffolds for Congenital Heart Disease
Congenital heart disease (CHD) is the most predominant birth defect and can require several invasive surgeries throughout childhood. The absence of materials with growth and remodelling potential is a limitation of currently used prosthetics in cardiovascular surgery, as well as their susceptibility...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/1/57 |
| _version_ | 1827628470256009216 |
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| author | Amy G. Harris Tasneem Salih Mohamed T. Ghorbel Massimo Caputo Giovanni Biglino Michele Carrabba |
| author_facet | Amy G. Harris Tasneem Salih Mohamed T. Ghorbel Massimo Caputo Giovanni Biglino Michele Carrabba |
| author_sort | Amy G. Harris |
| collection | DOAJ |
| description | Congenital heart disease (CHD) is the most predominant birth defect and can require several invasive surgeries throughout childhood. The absence of materials with growth and remodelling potential is a limitation of currently used prosthetics in cardiovascular surgery, as well as their susceptibility to calcification. The field of tissue engineering has emerged as a regenerative medicine approach aiming to develop durable scaffolds possessing the ability to grow and remodel upon implantation into the defective hearts of babies and children with CHD. Though tissue engineering has produced several synthetic scaffolds, most of them failed to be successfully translated in this life-endangering clinical scenario, and currently, biological scaffolds are the most extensively used. This review aims to thoroughly summarise the existing biological scaffolds for the treatment of paediatric CHD, categorised as homografts and xenografts, and present the preclinical and clinical studies. Fixation as well as techniques of decellularisation will be reported, highlighting the importance of these approaches for the successful implantation of biological scaffolds that avoid prosthetic rejection. Additionally, cardiac scaffolds for paediatric CHD can be implanted as acellular prostheses, or recellularised before implantation, and cellularisation techniques will be extensively discussed. |
| first_indexed | 2024-03-09T13:33:47Z |
| format | Article |
| id | doaj.art-4c282c09353a44a38c332b808166f3aa |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T13:33:47Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-4c282c09353a44a38c332b808166f3aa2023-11-30T21:14:52ZengMDPI AGBioengineering2306-53542023-01-011015710.3390/bioengineering10010057Biological Scaffolds for Congenital Heart DiseaseAmy G. Harris0Tasneem Salih1Mohamed T. Ghorbel2Massimo Caputo3Giovanni Biglino4Michele Carrabba5Bristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 89HW, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 89HW, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 89HW, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 89HW, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 89HW, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 89HW, UKCongenital heart disease (CHD) is the most predominant birth defect and can require several invasive surgeries throughout childhood. The absence of materials with growth and remodelling potential is a limitation of currently used prosthetics in cardiovascular surgery, as well as their susceptibility to calcification. The field of tissue engineering has emerged as a regenerative medicine approach aiming to develop durable scaffolds possessing the ability to grow and remodel upon implantation into the defective hearts of babies and children with CHD. Though tissue engineering has produced several synthetic scaffolds, most of them failed to be successfully translated in this life-endangering clinical scenario, and currently, biological scaffolds are the most extensively used. This review aims to thoroughly summarise the existing biological scaffolds for the treatment of paediatric CHD, categorised as homografts and xenografts, and present the preclinical and clinical studies. Fixation as well as techniques of decellularisation will be reported, highlighting the importance of these approaches for the successful implantation of biological scaffolds that avoid prosthetic rejection. Additionally, cardiac scaffolds for paediatric CHD can be implanted as acellular prostheses, or recellularised before implantation, and cellularisation techniques will be extensively discussed.https://www.mdpi.com/2306-5354/10/1/57congenital heart diseasechildrentissue engineeringscaffoldsgrowfixation |
| spellingShingle | Amy G. Harris Tasneem Salih Mohamed T. Ghorbel Massimo Caputo Giovanni Biglino Michele Carrabba Biological Scaffolds for Congenital Heart Disease Bioengineering congenital heart disease children tissue engineering scaffolds grow fixation |
| title | Biological Scaffolds for Congenital Heart Disease |
| title_full | Biological Scaffolds for Congenital Heart Disease |
| title_fullStr | Biological Scaffolds for Congenital Heart Disease |
| title_full_unstemmed | Biological Scaffolds for Congenital Heart Disease |
| title_short | Biological Scaffolds for Congenital Heart Disease |
| title_sort | biological scaffolds for congenital heart disease |
| topic | congenital heart disease children tissue engineering scaffolds grow fixation |
| url | https://www.mdpi.com/2306-5354/10/1/57 |
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