Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
In modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health probl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/9/4/87 |
| _version_ | 1797505387053711360 |
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| author | Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand |
| author_facet | Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand |
| author_sort | Abdelaziz Ghanemi |
| collection | DOAJ |
| description | In modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health problems. Both of these health problems also share exercise and a healthy lifestyle as the best therapeutic options. Importantly, ageing and obesity also have common epigenetic changes (histone modification, DNA methylation, noncoding RNAs, and chromatin remodeling) that are also impacted by exercise. This suggests that epigenetic pathways are among the mechanisms via which exercise induces its benefits, including ageing and obesity improvements. Exploring these interrelations and based on the fact that both ageing and obesity represent risk factors for each other, would lead to optimizing the available therapeutic approaches towards improved obesity management and healthy ageing. |
| first_indexed | 2024-03-10T04:17:55Z |
| format | Article |
| id | doaj.art-4c29363eeab24ef09b5789fe44e710fb |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T04:17:55Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-4c29363eeab24ef09b5789fe44e710fb2023-11-23T07:55:57ZengMDPI AGDiseases2079-97212021-11-01948710.3390/diseases9040087Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to EpigeneticsAbdelaziz Ghanemi0Mayumi Yoshioka1Jonny St-Amand2Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec City, QC G1V 4G2, CanadaFunctional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec City, QC G1V 4G2, CanadaFunctional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec City, QC G1V 4G2, CanadaIn modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health problems. Both of these health problems also share exercise and a healthy lifestyle as the best therapeutic options. Importantly, ageing and obesity also have common epigenetic changes (histone modification, DNA methylation, noncoding RNAs, and chromatin remodeling) that are also impacted by exercise. This suggests that epigenetic pathways are among the mechanisms via which exercise induces its benefits, including ageing and obesity improvements. Exploring these interrelations and based on the fact that both ageing and obesity represent risk factors for each other, would lead to optimizing the available therapeutic approaches towards improved obesity management and healthy ageing.https://www.mdpi.com/2079-9721/9/4/87obesityageingepigeneticspathogenesisexercise |
| spellingShingle | Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics Diseases obesity ageing epigenetics pathogenesis exercise |
| title | Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics |
| title_full | Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics |
| title_fullStr | Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics |
| title_full_unstemmed | Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics |
| title_short | Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics |
| title_sort | ageing and obesity shared patterns from molecular pathogenesis to epigenetics |
| topic | obesity ageing epigenetics pathogenesis exercise |
| url | https://www.mdpi.com/2079-9721/9/4/87 |
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