Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma

Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma

Abstract The innate immune stimulator of interferon genes (STING) pathway is known to activate type I interferons (IFN-I) and participate in generating antitumor immunity. We previously produced hDT806, a recombinant diphtheria immunotoxin, and demonstrated its efficacy against head and neck squamou...

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Bibliographic Details
Main Authors: Guiqin Xie, Liang Shan, Cuicui Yang, Yuanyi Liu, Xiaowu Pang, Shaolei Teng, Tzyy-Choou Wu, Xinbin Gu
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45797-7

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