Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study
BackgroundPremature rupture of membranes (PROM) is a common cause of extremely premature infants (EPIs) and also leads to adverse preterm complications. However, the effect of PROM on EPIs remains contradictory. This study used propensity score matching (PSM) to adjust the baseline characteristics t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1144373/full |
| _version_ | 1797856204576260096 |
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| author | Jing-Ke Cao Chang-Geng Liu Dan Wang Qiu-Ping Li Qiu-Ping Li |
| author_facet | Jing-Ke Cao Chang-Geng Liu Dan Wang Qiu-Ping Li Qiu-Ping Li |
| author_sort | Jing-Ke Cao |
| collection | DOAJ |
| description | BackgroundPremature rupture of membranes (PROM) is a common cause of extremely premature infants (EPIs) and also leads to adverse preterm complications. However, the effect of PROM on EPIs remains contradictory. This study used propensity score matching (PSM) to adjust the baseline characteristics to explore the impact of PROM on clinical outcomes of extremely premature infants (EPIs).MethodsMedical data of 470 EPIs at gestational age < 28weeks who received prenatal examination in our hospital between January 1, 2015 and December 31, 2020 were analyzed retrospectively. According to the presence or absence of PROM, they were divided into a PROM group and a non-PROM group. Ten covariates including birth weight, male sex, artificial conception, cesarean delivery, 5-min Apgar score ≤ 7, oligohydramnios, gestational hypertension, preeclampsia, antenatal steroid use, and complete steroid treatment were matched 1:1 by PSM. The major complication occurrence and mortality during hospitalization were compared between the two groups by t-test, nonparametric test or x2 test.ResultsAmong the 470 infants enrolled, 157 (33.4%) were in the PROM group and 313 in the no-PROM group. After matching the ten confounding factors,276 cases were successfully enrolled. The incidence of early pulmonary hypertension (EPH) and severe retinopathy of prematurity (ROP) in the PROM group were higher than those in the no-PROM group [44.2% (61/138) vs. 29.0% (40/138); 34.8% (48/138) vs. 21.7% (30/138), x2 = 6.886 and 5.790, both P < 0.05]. However, there was no significant difference in the in-hospital mortality and the incidence of other major complications between the two groups (all P > 0.05).ConclusionsPROM increased the incidence of EPH and severe ROP in EPI, but had no significant impact on in-hospital mortality, length of hospital stay, and the incidence of other complications. |
| first_indexed | 2024-04-09T20:36:39Z |
| format | Article |
| id | doaj.art-4c2be24386d941d8af21288fe62f0d7b |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T20:36:39Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-4c2be24386d941d8af21288fe62f0d7b2023-03-30T07:31:12ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.11443731144373Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching studyJing-Ke Cao0Chang-Geng Liu1Dan Wang2Qiu-Ping Li3Qiu-Ping Li4The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Neonatology, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, ChinaBackgroundPremature rupture of membranes (PROM) is a common cause of extremely premature infants (EPIs) and also leads to adverse preterm complications. However, the effect of PROM on EPIs remains contradictory. This study used propensity score matching (PSM) to adjust the baseline characteristics to explore the impact of PROM on clinical outcomes of extremely premature infants (EPIs).MethodsMedical data of 470 EPIs at gestational age < 28weeks who received prenatal examination in our hospital between January 1, 2015 and December 31, 2020 were analyzed retrospectively. According to the presence or absence of PROM, they were divided into a PROM group and a non-PROM group. Ten covariates including birth weight, male sex, artificial conception, cesarean delivery, 5-min Apgar score ≤ 7, oligohydramnios, gestational hypertension, preeclampsia, antenatal steroid use, and complete steroid treatment were matched 1:1 by PSM. The major complication occurrence and mortality during hospitalization were compared between the two groups by t-test, nonparametric test or x2 test.ResultsAmong the 470 infants enrolled, 157 (33.4%) were in the PROM group and 313 in the no-PROM group. After matching the ten confounding factors,276 cases were successfully enrolled. The incidence of early pulmonary hypertension (EPH) and severe retinopathy of prematurity (ROP) in the PROM group were higher than those in the no-PROM group [44.2% (61/138) vs. 29.0% (40/138); 34.8% (48/138) vs. 21.7% (30/138), x2 = 6.886 and 5.790, both P < 0.05]. However, there was no significant difference in the in-hospital mortality and the incidence of other major complications between the two groups (all P > 0.05).ConclusionsPROM increased the incidence of EPH and severe ROP in EPI, but had no significant impact on in-hospital mortality, length of hospital stay, and the incidence of other complications.https://www.frontiersin.org/articles/10.3389/fped.2023.1144373/fullextremely premature infantspremature rupture of membranes (PROM)propensity score matching (PSM)disease prognosiscomplications |
| spellingShingle | Jing-Ke Cao Chang-Geng Liu Dan Wang Qiu-Ping Li Qiu-Ping Li Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study Frontiers in Pediatrics extremely premature infants premature rupture of membranes (PROM) propensity score matching (PSM) disease prognosis complications |
| title | Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study |
| title_full | Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study |
| title_fullStr | Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study |
| title_full_unstemmed | Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study |
| title_short | Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study |
| title_sort | impact of premature rupture of membranes on clinical outcomes of extremely premature infants a propensity score matching study |
| topic | extremely premature infants premature rupture of membranes (PROM) propensity score matching (PSM) disease prognosis complications |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1144373/full |
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