Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes
<p>Abstract</p> <p>Background</p> <p>Neuroinflammation has been known to play a critical role in the pathogenesis of Alzheimer's disease (AD). Activation of microglia and astrocytes is a characteristic of brain inflammation. Epidemiological studies have shown that...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-08-01
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| Series: | Journal of Neuroinflammation |
| Online Access: | http://www.jneuroinflammation.com/content/8/1/98 |
| _version_ | 1811246882156969984 |
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| author | Du Guanhua Zhang Tiantai Sun Lan Liu Rui Lan Xi |
| author_facet | Du Guanhua Zhang Tiantai Sun Lan Liu Rui Lan Xi |
| author_sort | Du Guanhua |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Neuroinflammation has been known to play a critical role in the pathogenesis of Alzheimer's disease (AD). Activation of microglia and astrocytes is a characteristic of brain inflammation. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) delays the onset of AD and suppresses its progression. Methyl salicylate-2-<it>O</it>-<it>β</it>-<smcaps/><smcaps>D</smcaps>-lactoside (DL0309) is a new molecule chemically related to salicylic acid. The present study aimed to evaluate the anti-inflammatory effects of DL0309.</p> <p>Findings</p> <p>Our studies show that DL0309 significantly inhibits lipopolysaccharide (LPS)-induced release of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; and the expression of the inflammation-related proteins iNOS, COX-1, and COX-2 by microglia and astrocytes. At a concentration of 10 μM, DL0309 prominently inhibited LPS-induced activation of NF-κB in glial cells by blocking phosphorylation of IKK and p65, and by blocking IκB degradation.</p> <p>Conclusions</p> <p>We demonstrate here for the first time that DL0309 exerts anti-inflammatory effects in glial cells by suppressing different pro-inflammatory cytokines and iNOS/NO. Furthermore, it also regulates the NF-κB signaling pathway by blocking IKK and p65 activation and IκB degradation. DL0309 also acts as a non-selective COX inhibitor in glial cells. These studies suggest that DL0309 may be effective in the treatment of neuroinflammatory disorders, including AD.</p> |
| first_indexed | 2024-04-12T15:00:50Z |
| format | Article |
| id | doaj.art-4c2cdd254b3a484eac4ba90dcae4f291 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-12T15:00:50Z |
| publishDate | 2011-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-4c2cdd254b3a484eac4ba90dcae4f2912022-12-22T03:28:05ZengBMCJournal of Neuroinflammation1742-20942011-08-01819810.1186/1742-2094-8-98Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytesDu GuanhuaZhang TiantaiSun LanLiu RuiLan Xi<p>Abstract</p> <p>Background</p> <p>Neuroinflammation has been known to play a critical role in the pathogenesis of Alzheimer's disease (AD). Activation of microglia and astrocytes is a characteristic of brain inflammation. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) delays the onset of AD and suppresses its progression. Methyl salicylate-2-<it>O</it>-<it>β</it>-<smcaps/><smcaps>D</smcaps>-lactoside (DL0309) is a new molecule chemically related to salicylic acid. The present study aimed to evaluate the anti-inflammatory effects of DL0309.</p> <p>Findings</p> <p>Our studies show that DL0309 significantly inhibits lipopolysaccharide (LPS)-induced release of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; and the expression of the inflammation-related proteins iNOS, COX-1, and COX-2 by microglia and astrocytes. At a concentration of 10 μM, DL0309 prominently inhibited LPS-induced activation of NF-κB in glial cells by blocking phosphorylation of IKK and p65, and by blocking IκB degradation.</p> <p>Conclusions</p> <p>We demonstrate here for the first time that DL0309 exerts anti-inflammatory effects in glial cells by suppressing different pro-inflammatory cytokines and iNOS/NO. Furthermore, it also regulates the NF-κB signaling pathway by blocking IKK and p65 activation and IκB degradation. DL0309 also acts as a non-selective COX inhibitor in glial cells. These studies suggest that DL0309 may be effective in the treatment of neuroinflammatory disorders, including AD.</p>http://www.jneuroinflammation.com/content/8/1/98 |
| spellingShingle | Du Guanhua Zhang Tiantai Sun Lan Liu Rui Lan Xi Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes Journal of Neuroinflammation |
| title | Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes |
| title_full | Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes |
| title_fullStr | Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes |
| title_full_unstemmed | Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes |
| title_short | Methyl salicylate 2-<it>O</it>-<it>β</it>-<smcaps><smcaps/><smcaps>D</smcaps></smcaps>-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes |
| title_sort | methyl salicylate 2 it o it it β it smcaps smcaps smcaps d smcaps smcaps lactoside a novel salicylic acid analogue acts as an anti inflammatory agent on microglia and astrocytes |
| url | http://www.jneuroinflammation.com/content/8/1/98 |
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