Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study
Objectives The etiology of exocrine pancreatic cancer (EPC) remains unknown except for family history and smoking. Despite recent medical advances, rates of pancreatic cancer incidence and mortality are increasing. Although existing evidence suggests a potentially causal relationship between environ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nofer Institute of Occupational Medicine
2022-07-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
| Subjects: | |
| Online Access: | http://ijomeh.eu/Exocrine-pancreatic-cancer-and-living-near-to-waste-sites-containing-hazardous-organic,145794,0,2.html |
| _version_ | 1818084814055538688 |
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| author | Bayarmagnai Weinstein Alan da Silva David O. Carpenter |
| author_facet | Bayarmagnai Weinstein Alan da Silva David O. Carpenter |
| author_sort | Bayarmagnai Weinstein |
| collection | DOAJ |
| description | Objectives
The etiology of exocrine pancreatic cancer (EPC) remains unknown except for family history and smoking. Despite recent medical advances, rates of pancreatic cancer incidence and mortality are increasing. Although existing evidence suggests a potentially causal relationship
between environmental chemical exposures and pancreatic cancer, whether residential exposure impacts pancreatic cancer rates remains unknown.
Material and Methods
The authors identified 28 941 patients diagnosed with exocrine pancreatic cancer in New York State exclusive of New York
City for the years 1996–2013. Descriptive statistics and negative binomial regression were used in this ecological study to compare pancreatic cancer
hospitalization rates among patients who lived in zip codes with hazardous waste sites (HWSs) containing persistent organic pollutants (POPs)
and volatile organic pollutants (VOCs) compared with clean zip codes with no identified hazardous waste sites. The authors assessed the effect of
selected known and suspected human carcinogens on the EPC hospitalization rates by subgroup analyses.
Results
Compared with the clean sites,
the pancreatic cancer hospital discharge rate in the “VOCs without POPs” and “VOCs and POPs” sites, after adjustment for potential confounders
were 1.06 (95% CI: 1.03–1.09) and 1.05 (95% CI: 1.01–1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene
(RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11)
in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values
<0.05) compared with clean sites.
Conclusions
Compared with the clean sites,
the pancreatic cancer hospital discharge rate in the “VOCs without POPs” and “VOCs and POPs” sites, after adjustment for potential confounders
were 1.06 (95% CI: 1.03–1.09) and 1.05 (95% CI: 1.01–1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene
(RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11)
in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values
<0.05) compared with clean sites. Int J Occup Med Environ Health. 2022;35(4):459–71 |
| first_indexed | 2024-12-10T19:59:52Z |
| format | Article |
| id | doaj.art-4c2cfde2534b4814a69bc1c394e05477 |
| institution | Directory Open Access Journal |
| issn | 1232-1087 1896-494X |
| language | English |
| last_indexed | 2024-12-10T19:59:52Z |
| publishDate | 2022-07-01 |
| publisher | Nofer Institute of Occupational Medicine |
| record_format | Article |
| series | International Journal of Occupational Medicine and Environmental Health |
| spelling | doaj.art-4c2cfde2534b4814a69bc1c394e054772022-12-22T01:35:32ZengNofer Institute of Occupational MedicineInternational Journal of Occupational Medicine and Environmental Health1232-10871896-494X2022-07-0135445947110.13075/ijomeh.1896.01886145794Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based studyBayarmagnai Weinstein0Alan da Silva1David O. Carpenter2University at Albany, Rensselaer, NY, USA (Department of Environmental Health Sciences, School of Public Health)University of Brasília, Brasília, Brazil (Department of Statistics)University at Albany, Rensselaer, NY, USA (Department of Environmental Health Sciences, School of Public Health)Objectives The etiology of exocrine pancreatic cancer (EPC) remains unknown except for family history and smoking. Despite recent medical advances, rates of pancreatic cancer incidence and mortality are increasing. Although existing evidence suggests a potentially causal relationship between environmental chemical exposures and pancreatic cancer, whether residential exposure impacts pancreatic cancer rates remains unknown. Material and Methods The authors identified 28 941 patients diagnosed with exocrine pancreatic cancer in New York State exclusive of New York City for the years 1996–2013. Descriptive statistics and negative binomial regression were used in this ecological study to compare pancreatic cancer hospitalization rates among patients who lived in zip codes with hazardous waste sites (HWSs) containing persistent organic pollutants (POPs) and volatile organic pollutants (VOCs) compared with clean zip codes with no identified hazardous waste sites. The authors assessed the effect of selected known and suspected human carcinogens on the EPC hospitalization rates by subgroup analyses. Results Compared with the clean sites, the pancreatic cancer hospital discharge rate in the “VOCs without POPs” and “VOCs and POPs” sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03–1.09) and 1.05 (95% CI: 1.01–1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites. Conclusions Compared with the clean sites, the pancreatic cancer hospital discharge rate in the “VOCs without POPs” and “VOCs and POPs” sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03–1.09) and 1.05 (95% CI: 1.01–1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites. Int J Occup Med Environ Health. 2022;35(4):459–71http://ijomeh.eu/Exocrine-pancreatic-cancer-and-living-near-to-waste-sites-containing-hazardous-organic,145794,0,2.htmlbenzenepancreatic cancerpesticidesresidential exposurevocspcbs |
| spellingShingle | Bayarmagnai Weinstein Alan da Silva David O. Carpenter Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study International Journal of Occupational Medicine and Environmental Health benzene pancreatic cancer pesticides residential exposure vocs pcbs |
| title | Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study |
| title_full | Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study |
| title_fullStr | Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study |
| title_full_unstemmed | Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study |
| title_short | Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study |
| title_sort | exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals new york state usa an 18 year population based study |
| topic | benzene pancreatic cancer pesticides residential exposure vocs pcbs |
| url | http://ijomeh.eu/Exocrine-pancreatic-cancer-and-living-near-to-waste-sites-containing-hazardous-organic,145794,0,2.html |
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