Delta Opioid Receptors and Enkephalinergic Signaling within Locus Coeruleus Promote Stress Resilience

Delta Opioid Receptors and Enkephalinergic Signaling within Locus Coeruleus Promote Stress Resilience

The noradrenergic nucleus locus coeruleus is a key component of the stress circuitry of the brain. During stress, the neuropeptide corticotropin-releasing factor (CRF) is secreted onto LC, increasing LC output and norepinephrine concentration in the brain, which is thought to promote anxiety-like be...

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Bibliographic Details
Main Authors: John A. Tkaczynski, Olga Borodovitsyna, Daniel J. Chandler
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Brain Sciences
Subjects:
locus coeruleus
stress
enkephalin
delta opioid receptors
anxiety-like behavior
Online Access:https://www.mdpi.com/2076-3425/12/7/860

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