5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
<p>Abstract</p> <p>Background</p> <p>Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loade...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/10/402 |
| _version_ | 1811245711737487360 |
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| author | Shi Huashan Shi Shuai Wu Qinjie Yang Li Gong Changyang Wang Yongsheng Qian Zhiyong Wei Yuquan |
| author_facet | Shi Huashan Shi Shuai Wu Qinjie Yang Li Gong Changyang Wang Yongsheng Qian Zhiyong Wei Yuquan |
| author_sort | Shi Huashan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy.</p> <p>Methods</p> <p>A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model.</p> <p>Results</p> <p>The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity.</p> <p>Conclusions</p> <p>Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.</p> |
| first_indexed | 2024-04-12T14:43:17Z |
| format | Article |
| id | doaj.art-4c2e8af8d5bf46e1bb401f86ab521eb4 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T14:43:17Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-4c2e8af8d5bf46e1bb401f86ab521eb42022-12-22T03:28:44ZengBMCBMC Cancer1471-24072010-08-0110140210.1186/1471-2407-10-4025-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in miceShi HuashanShi ShuaiWu QinjieYang LiGong ChangyangWang YongshengQian ZhiyongWei Yuquan<p>Abstract</p> <p>Background</p> <p>Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy.</p> <p>Methods</p> <p>A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model.</p> <p>Results</p> <p>The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity.</p> <p>Conclusions</p> <p>Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.</p>http://www.biomedcentral.com/1471-2407/10/402 |
| spellingShingle | Shi Huashan Shi Shuai Wu Qinjie Yang Li Gong Changyang Wang Yongsheng Qian Zhiyong Wei Yuquan 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice BMC Cancer |
| title | 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice |
| title_full | 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice |
| title_fullStr | 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice |
| title_full_unstemmed | 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice |
| title_short | 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice |
| title_sort | 5 fu hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice |
| url | http://www.biomedcentral.com/1471-2407/10/402 |
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