Extracellular Vesicles in Skin Wound Healing
Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/8/811 |
| _version_ | 1827684359450132480 |
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| author | Deimantė Narauskaitė Gabrielė Vydmantaitė Justina Rusteikaitė Revathi Sampath Akvilė Rudaitytė Gabija Stašytė María Isabel Aparicio Calvente Aistė Jekabsone |
| author_facet | Deimantė Narauskaitė Gabrielė Vydmantaitė Justina Rusteikaitė Revathi Sampath Akvilė Rudaitytė Gabija Stašytė María Isabel Aparicio Calvente Aistė Jekabsone |
| author_sort | Deimantė Narauskaitė |
| collection | DOAJ |
| description | Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs. |
| first_indexed | 2024-03-10T08:29:09Z |
| format | Article |
| id | doaj.art-4c2f622d5d6c489495aa0cf0ee249112 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T08:29:09Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-4c2f622d5d6c489495aa0cf0ee2491122023-11-22T09:12:12ZengMDPI AGPharmaceuticals1424-82472021-08-0114881110.3390/ph14080811Extracellular Vesicles in Skin Wound HealingDeimantė Narauskaitė0Gabrielė Vydmantaitė1Justina Rusteikaitė2Revathi Sampath3Akvilė Rudaitytė4Gabija Stašytė5María Isabel Aparicio Calvente6Aistė Jekabsone7Laboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaLaboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaPreclinical Research Laboratory for Medicinal Products, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaPreclinical Research Laboratory for Medicinal Products, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaLaboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaLaboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaLaboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaLaboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, LithuaniaEach year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.https://www.mdpi.com/1424-8247/14/8/811extracellular vesiclesEVsexosomesmesenchymal stem cell EVsplant-derived EVswound healing |
| spellingShingle | Deimantė Narauskaitė Gabrielė Vydmantaitė Justina Rusteikaitė Revathi Sampath Akvilė Rudaitytė Gabija Stašytė María Isabel Aparicio Calvente Aistė Jekabsone Extracellular Vesicles in Skin Wound Healing Pharmaceuticals extracellular vesicles EVs exosomes mesenchymal stem cell EVs plant-derived EVs wound healing |
| title | Extracellular Vesicles in Skin Wound Healing |
| title_full | Extracellular Vesicles in Skin Wound Healing |
| title_fullStr | Extracellular Vesicles in Skin Wound Healing |
| title_full_unstemmed | Extracellular Vesicles in Skin Wound Healing |
| title_short | Extracellular Vesicles in Skin Wound Healing |
| title_sort | extracellular vesicles in skin wound healing |
| topic | extracellular vesicles EVs exosomes mesenchymal stem cell EVs plant-derived EVs wound healing |
| url | https://www.mdpi.com/1424-8247/14/8/811 |
| work_keys_str_mv | AT deimantenarauskaite extracellularvesiclesinskinwoundhealing AT gabrielevydmantaite extracellularvesiclesinskinwoundhealing AT justinarusteikaite extracellularvesiclesinskinwoundhealing AT revathisampath extracellularvesiclesinskinwoundhealing AT akvilerudaityte extracellularvesiclesinskinwoundhealing AT gabijastasyte extracellularvesiclesinskinwoundhealing AT mariaisabelapariciocalvente extracellularvesiclesinskinwoundhealing AT aistejekabsone extracellularvesiclesinskinwoundhealing |