Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection
Abstract Gold magnetic nanoparticles (GoldMag) have attracted great attention due to their unique physical and chemical performances combining those of individual Fe3O4 and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-09-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-017-2303-6 |
| _version_ | 1797715638077095936 |
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| author | Xiaomei Zhang Qinlu Zhang Ting Ma Qian Liu Songdi Wu Kai Hua Chao Zhang Mingwei Chen Yali Cui |
| author_facet | Xiaomei Zhang Qinlu Zhang Ting Ma Qian Liu Songdi Wu Kai Hua Chao Zhang Mingwei Chen Yali Cui |
| author_sort | Xiaomei Zhang |
| collection | DOAJ |
| description | Abstract Gold magnetic nanoparticles (GoldMag) have attracted great attention due to their unique physical and chemical performances combining those of individual Fe3O4 and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer but also plays a key role for establishing point-of-care optical tests for clinically relevant biomolecules. In the present paper, poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA), a negatively charged polyelectrolyte with both sulfonate and carboxylate anionic groups, was used to coat the positively charged GoldMag (30 nm) surface. The PSS-MA-coated GoldMag complex has a stable plasmon resonance adsorption peak at 544 nm. A pair of anti-D-dimer antibodies has been coupled on this GoldMag composite nanoparticle surface, and a target protein, D-dimer was detected, in the range of 0.3–6 μg/mL. The shift of the characteristic peak, caused by the assembly of GoldMag due to the formation of D-dimer-antibody sandwich bridges, allowed the detection. |
| first_indexed | 2024-03-12T08:10:37Z |
| format | Article |
| id | doaj.art-4c30a39831594f98a8d8eab5c1b8379b |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T08:10:37Z |
| publishDate | 2017-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-4c30a39831594f98a8d8eab5c1b8379b2023-09-02T19:10:32ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2017-09-011211910.1186/s11671-017-2303-6Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein DetectionXiaomei Zhang0Qinlu Zhang1Ting Ma2Qian Liu3Songdi Wu4Kai Hua5Chao Zhang6Mingwei Chen7Yali Cui8College of Life Sciences, Northwest UniversitySchool of Medicine, The First Affiliated Hospital of Xi’an Jiaotong UniversityCollege of Life Sciences, Northwest UniversityCollege of Life Sciences, Northwest UniversityNo. 1 Hospital of Xi’an CityCollege of Life Sciences, Northwest UniversityCollege of Life Sciences, Northwest UniversitySchool of Medicine, The First Affiliated Hospital of Xi’an Jiaotong UniversityCollege of Life Sciences, Northwest UniversityAbstract Gold magnetic nanoparticles (GoldMag) have attracted great attention due to their unique physical and chemical performances combining those of individual Fe3O4 and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer but also plays a key role for establishing point-of-care optical tests for clinically relevant biomolecules. In the present paper, poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA), a negatively charged polyelectrolyte with both sulfonate and carboxylate anionic groups, was used to coat the positively charged GoldMag (30 nm) surface. The PSS-MA-coated GoldMag complex has a stable plasmon resonance adsorption peak at 544 nm. A pair of anti-D-dimer antibodies has been coupled on this GoldMag composite nanoparticle surface, and a target protein, D-dimer was detected, in the range of 0.3–6 μg/mL. The shift of the characteristic peak, caused by the assembly of GoldMag due to the formation of D-dimer-antibody sandwich bridges, allowed the detection.http://link.springer.com/article/10.1186/s11671-017-2303-6Poly(4-styrenesulfonic acid-co-maleic acid) sodium saltGold magnetic nanoparticlesDispersityConjugationProtein detection |
| spellingShingle | Xiaomei Zhang Qinlu Zhang Ting Ma Qian Liu Songdi Wu Kai Hua Chao Zhang Mingwei Chen Yali Cui Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection Nanoscale Research Letters Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt Gold magnetic nanoparticles Dispersity Conjugation Protein detection |
| title | Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection |
| title_full | Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection |
| title_fullStr | Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection |
| title_full_unstemmed | Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection |
| title_short | Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection |
| title_sort | enhanced stability of gold magnetic nanoparticles with poly 4 styrenesulfonic acid co maleic acid tailored optical properties for protein detection |
| topic | Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt Gold magnetic nanoparticles Dispersity Conjugation Protein detection |
| url | http://link.springer.com/article/10.1186/s11671-017-2303-6 |
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