Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas
Background: In cancers of prostate, breast, oropharynx, lung, hypopharynx and skin, human tissue kallikreins has been demonstrated as a main role in these problems. There are many research works in which some human tissue kallikreins are expressed in salivary glands. In the present study, the main g...
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| Format: | Article |
| Language: | English |
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Iranian Society of Pathology
2016-10-01
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| Series: | Iranian Journal of Pathology |
| Subjects: | |
| Online Access: | https://ijp.iranpath.org/article_22233_606144085c798ff2c1d5f8a511f229c8.pdf |
| _version_ | 1819008875780636672 |
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| author | Maryam Alsadat Hashemipour Fatemeh Sadat Fatah Mohammad Javad Ashraf Mehrnaz Tahmasebi |
| author_facet | Maryam Alsadat Hashemipour Fatemeh Sadat Fatah Mohammad Javad Ashraf Mehrnaz Tahmasebi |
| author_sort | Maryam Alsadat Hashemipour |
| collection | DOAJ |
| description | Background: In cancers of prostate, breast, oropharynx, lung, hypopharynx and skin, human tissue kallikreins has been demonstrated as a main role in these problems. There are many research works in which some human tissue kallikreins are expressed in salivary glands. In the present study, the main goal was to determine expression of human tissue kallikreins 4, 8, 10, 11 and 13 in pleomorphic adenomas and mucoepidermoid carcinomas. Methods: Sixty-six specimens (45 cases of pleomorphic adenomas and 21 cases mucoepidermoid carcinomas) were selected for final analysis by immunohistochemistry. For doing association test, clinical parameters obtained from the patients’ medical charts, which included age, gender were used and the nonparametric tests employed for statistical analyses. Results: The expression of human kallikreins 4, 8, 11 and 13 was more prominent in benign and malignant tumors compared to that in normal tissues and the difference was significant. In addition, the expression of human kallikreins 4, 8, 10 and 11 in malignant tumors was more than that in benign tumors, with statistically significant differences. Conclusion: The differences in the levels of human kallikreins 4, 8, 11 and 13 suggest that kallikreins may benefit in determining tumor behavior of salivary gland tumors. |
| first_indexed | 2024-12-21T00:47:26Z |
| format | Article |
| id | doaj.art-4c31211f7762480098cfaba03230a83f |
| institution | Directory Open Access Journal |
| issn | 1735-5303 2345-3656 |
| language | English |
| last_indexed | 2024-12-21T00:47:26Z |
| publishDate | 2016-10-01 |
| publisher | Iranian Society of Pathology |
| record_format | Article |
| series | Iranian Journal of Pathology |
| spelling | doaj.art-4c31211f7762480098cfaba03230a83f2022-12-21T19:21:28ZengIranian Society of PathologyIranian Journal of Pathology1735-53032345-36562016-10-0111433434422233Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid CarcinomasMaryam Alsadat Hashemipour0Fatemeh Sadat Fatah1Mohammad Javad Ashraf2Mehrnaz Tahmasebi3Kerman Dental and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, IranDept. of Oral Medicine, School of Dentistry, Shiraz University International Division, Shiraz, IranDept of Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranKerman Social Determinants on Oral Health Research Center, Kerman University of Medical Sciences, Kerman, IranBackground: In cancers of prostate, breast, oropharynx, lung, hypopharynx and skin, human tissue kallikreins has been demonstrated as a main role in these problems. There are many research works in which some human tissue kallikreins are expressed in salivary glands. In the present study, the main goal was to determine expression of human tissue kallikreins 4, 8, 10, 11 and 13 in pleomorphic adenomas and mucoepidermoid carcinomas. Methods: Sixty-six specimens (45 cases of pleomorphic adenomas and 21 cases mucoepidermoid carcinomas) were selected for final analysis by immunohistochemistry. For doing association test, clinical parameters obtained from the patients’ medical charts, which included age, gender were used and the nonparametric tests employed for statistical analyses. Results: The expression of human kallikreins 4, 8, 11 and 13 was more prominent in benign and malignant tumors compared to that in normal tissues and the difference was significant. In addition, the expression of human kallikreins 4, 8, 10 and 11 in malignant tumors was more than that in benign tumors, with statistically significant differences. Conclusion: The differences in the levels of human kallikreins 4, 8, 11 and 13 suggest that kallikreins may benefit in determining tumor behavior of salivary gland tumors.https://ijp.iranpath.org/article_22233_606144085c798ff2c1d5f8a511f229c8.pdfhuman kallikreinsbenignmalignantsalivary gland tumors |
| spellingShingle | Maryam Alsadat Hashemipour Fatemeh Sadat Fatah Mohammad Javad Ashraf Mehrnaz Tahmasebi Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas Iranian Journal of Pathology human kallikreins benign malignant salivary gland tumors |
| title | Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas |
| title_full | Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas |
| title_fullStr | Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas |
| title_full_unstemmed | Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas |
| title_short | Expression of Human Kallikreins 4, 8, 10, 11 and 13 in Pleomorphic Adenomas and Mucoepidermoid Carcinomas |
| title_sort | expression of human kallikreins 4 8 10 11 and 13 in pleomorphic adenomas and mucoepidermoid carcinomas |
| topic | human kallikreins benign malignant salivary gland tumors |
| url | https://ijp.iranpath.org/article_22233_606144085c798ff2c1d5f8a511f229c8.pdf |
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