Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer
Abstract Background Genomic profiles of specific gene sets have been established to guide personalized treatment and prognosis for patients with breast cancer (BC). However, epigenomic information has not yet been applied in a clinical setting. ST14 encodes matriptase, a proteinase that is widely ex...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-08645-3 |
| _version_ | 1819096565419081728 |
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| author | Yang-Hong Dai Ying-Fu Wang Po-Chien Shen Cheng-Hsiang Lo Jen-Fu Yang Chun-Shu Lin Hsing-Lung Chao Wen-Yen Huang |
| author_facet | Yang-Hong Dai Ying-Fu Wang Po-Chien Shen Cheng-Hsiang Lo Jen-Fu Yang Chun-Shu Lin Hsing-Lung Chao Wen-Yen Huang |
| author_sort | Yang-Hong Dai |
| collection | DOAJ |
| description | Abstract Background Genomic profiles of specific gene sets have been established to guide personalized treatment and prognosis for patients with breast cancer (BC). However, epigenomic information has not yet been applied in a clinical setting. ST14 encodes matriptase, a proteinase that is widely expressed in BC with reported prognostic value. Methods In this present study, we evaluated the effect of ST14 DNA methylation (DNAm) on overall survival (OS) of patients with BC as a representative example to promote the use of the epigenome in clinical decisions. We analyzed publicly available genomic and epigenomic data from 1361 BC patients. Methylation was characterized by the β-value from CpG probes based on sequencing with the Illumina Human 450 K platform. Results A high mean DNAm (β > 0.6779) across 34 CpG probes for ST14, as the gene-associated methylation (GAM) pattern, was associated with a longer OS after adjusting age, stage, histology and molecular features in Cox model (p value < 0.001). A high GAM status was also associated with a higher XBP1 expression level and higher proportion of hormone-positive BC (p value < 0.001). Pathway analysis revealed that altered GAM was related to matrisome-associated pathway. Conclusions Here we show the potential role of ST14 DNAm in BC prognosis and warrant further study. |
| first_indexed | 2024-12-22T00:01:13Z |
| format | Article |
| id | doaj.art-4c325a96324d4bcbaa3b4a2535d9b922 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-22T00:01:13Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-4c325a96324d4bcbaa3b4a2535d9b9222022-12-21T18:45:42ZengBMCBMC Cancer1471-24072021-08-0121111410.1186/s12885-021-08645-3Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast CancerYang-Hong Dai0Ying-Fu Wang1Po-Chien Shen2Cheng-Hsiang Lo3Jen-Fu Yang4Chun-Shu Lin5Hsing-Lung Chao6Wen-Yen Huang7Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical CenterAbstract Background Genomic profiles of specific gene sets have been established to guide personalized treatment and prognosis for patients with breast cancer (BC). However, epigenomic information has not yet been applied in a clinical setting. ST14 encodes matriptase, a proteinase that is widely expressed in BC with reported prognostic value. Methods In this present study, we evaluated the effect of ST14 DNA methylation (DNAm) on overall survival (OS) of patients with BC as a representative example to promote the use of the epigenome in clinical decisions. We analyzed publicly available genomic and epigenomic data from 1361 BC patients. Methylation was characterized by the β-value from CpG probes based on sequencing with the Illumina Human 450 K platform. Results A high mean DNAm (β > 0.6779) across 34 CpG probes for ST14, as the gene-associated methylation (GAM) pattern, was associated with a longer OS after adjusting age, stage, histology and molecular features in Cox model (p value < 0.001). A high GAM status was also associated with a higher XBP1 expression level and higher proportion of hormone-positive BC (p value < 0.001). Pathway analysis revealed that altered GAM was related to matrisome-associated pathway. Conclusions Here we show the potential role of ST14 DNAm in BC prognosis and warrant further study.https://doi.org/10.1186/s12885-021-08645-3ST14MatriptaseDNA methylationBreast Cancer |
| spellingShingle | Yang-Hong Dai Ying-Fu Wang Po-Chien Shen Cheng-Hsiang Lo Jen-Fu Yang Chun-Shu Lin Hsing-Lung Chao Wen-Yen Huang Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer BMC Cancer ST14 Matriptase DNA methylation Breast Cancer |
| title | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer |
| title_full | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer |
| title_fullStr | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer |
| title_full_unstemmed | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer |
| title_short | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer |
| title_sort | gene associated methylation status of st14 as a predictor of survival and hormone receptor positivity in breast cancer |
| topic | ST14 Matriptase DNA methylation Breast Cancer |
| url | https://doi.org/10.1186/s12885-021-08645-3 |
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