Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial
Abstract Background Non-invasive techniques such as central intermittent theta burst stimulation (iTBS) and repetitive peripheral magnetic stimulation (rPMS) have shown promise in improving motor function for patients with stroke. However, the combined efficacy of rPMS and central iTBS has not been...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of NeuroEngineering and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12984-024-01341-w |
| _version_ | 1797209472014221312 |
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| author | Chi-Shou Chang Chia-Ling Chen Rou-Shayn Chen Hsieh-Ching Chen Chung-Yao Chen Chia-Ying Chung Katie Pei-Hsuan Wu Ching-Yi Wu Keh-chung Lin |
| author_facet | Chi-Shou Chang Chia-Ling Chen Rou-Shayn Chen Hsieh-Ching Chen Chung-Yao Chen Chia-Ying Chung Katie Pei-Hsuan Wu Ching-Yi Wu Keh-chung Lin |
| author_sort | Chi-Shou Chang |
| collection | DOAJ |
| description | Abstract Background Non-invasive techniques such as central intermittent theta burst stimulation (iTBS) and repetitive peripheral magnetic stimulation (rPMS) have shown promise in improving motor function for patients with stroke. However, the combined efficacy of rPMS and central iTBS has not been extensively studied. This randomized controlled trial aimed to investigate the synergistic effects of rPMS and central iTBS in patients with stroke. Method In this study, 28 stroke patients were randomly allocated to receive either 1200 pulses of real or sham rPMS on the radial nerve of the affected limb, followed by 1200 pulses of central iTBS on the ipsilesional hemisphere. The patients received the intervention for 10 sessions over two weeks. The primary outcome measures were the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and the Action Research Arm Test (ARAT). Secondary outcomes for activities and participation included the Functional Independence Measure-Selfcare (FIM-Selfcare) and the Stroke Impact Scale (SIS). The outcome measures were assessed before and after the intervention. Results Both groups showed significant improvement in FMA-UE and FIM-Selfcare after the intervention (p < 0.05). Only the rPMS + iTBS group had significant improvement in ARAT-Grasp and SIS-Strength and activity of daily living (p < 0.05). However, the change scores in all outcome measures did not differ between two groups. Conclusions Overall, the study’s findings suggest that rPMS may have a synergistic effect on central iTBS to improve grasp function and participation. In conclusion, these findings highlight the potential of rPMS as an adjuvant therapy for central iTBS in stroke rehabilitation. Further large-scale studies are needed to fully explore the synergistic effects of rPMS on central iTBS. Trial registration This trial was registered under ClinicalTrials.gov ID No.NCT04265365, retrospectively registered, on February 11, 2020. |
| first_indexed | 2024-04-24T09:55:14Z |
| format | Article |
| id | doaj.art-4c34fa37d971460f9cfda293fe98f045 |
| institution | Directory Open Access Journal |
| issn | 1743-0003 |
| language | English |
| last_indexed | 2024-04-24T09:55:14Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of NeuroEngineering and Rehabilitation |
| spelling | doaj.art-4c34fa37d971460f9cfda293fe98f0452024-04-14T11:09:26ZengBMCJournal of NeuroEngineering and Rehabilitation1743-00032024-04-0121111010.1186/s12984-024-01341-wSynergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trialChi-Shou Chang0Chia-Ling Chen1Rou-Shayn Chen2Hsieh-Ching Chen3Chung-Yao Chen4Chia-Ying Chung5Katie Pei-Hsuan Wu6Ching-Yi Wu7Keh-chung Lin8Department of Diagnostic Radiology, Chang Gung Memorial HospitalDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial HospitalDepartment of Medicine, College of Medicine, Chang Gung UniversityDepartment of Industrial Engineering and Management, National Taipei University of TechnologyDepartment of Medicine, College of Medicine, Chang Gung UniversityDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial HospitalDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial HospitalDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial HospitalSchool of Occupational Therapy, College of Medicine, National Taiwan UniversityAbstract Background Non-invasive techniques such as central intermittent theta burst stimulation (iTBS) and repetitive peripheral magnetic stimulation (rPMS) have shown promise in improving motor function for patients with stroke. However, the combined efficacy of rPMS and central iTBS has not been extensively studied. This randomized controlled trial aimed to investigate the synergistic effects of rPMS and central iTBS in patients with stroke. Method In this study, 28 stroke patients were randomly allocated to receive either 1200 pulses of real or sham rPMS on the radial nerve of the affected limb, followed by 1200 pulses of central iTBS on the ipsilesional hemisphere. The patients received the intervention for 10 sessions over two weeks. The primary outcome measures were the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and the Action Research Arm Test (ARAT). Secondary outcomes for activities and participation included the Functional Independence Measure-Selfcare (FIM-Selfcare) and the Stroke Impact Scale (SIS). The outcome measures were assessed before and after the intervention. Results Both groups showed significant improvement in FMA-UE and FIM-Selfcare after the intervention (p < 0.05). Only the rPMS + iTBS group had significant improvement in ARAT-Grasp and SIS-Strength and activity of daily living (p < 0.05). However, the change scores in all outcome measures did not differ between two groups. Conclusions Overall, the study’s findings suggest that rPMS may have a synergistic effect on central iTBS to improve grasp function and participation. In conclusion, these findings highlight the potential of rPMS as an adjuvant therapy for central iTBS in stroke rehabilitation. Further large-scale studies are needed to fully explore the synergistic effects of rPMS on central iTBS. Trial registration This trial was registered under ClinicalTrials.gov ID No.NCT04265365, retrospectively registered, on February 11, 2020.https://doi.org/10.1186/s12984-024-01341-wTheta burst stimulationPeripheral magnetic stimulationStrokeUpper limbMotor functionRehabilitation |
| spellingShingle | Chi-Shou Chang Chia-Ling Chen Rou-Shayn Chen Hsieh-Ching Chen Chung-Yao Chen Chia-Ying Chung Katie Pei-Hsuan Wu Ching-Yi Wu Keh-chung Lin Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial Journal of NeuroEngineering and Rehabilitation Theta burst stimulation Peripheral magnetic stimulation Stroke Upper limb Motor function Rehabilitation |
| title | Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial |
| title_full | Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial |
| title_fullStr | Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial |
| title_full_unstemmed | Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial |
| title_short | Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial |
| title_sort | synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke a double blinded randomized controlled trial |
| topic | Theta burst stimulation Peripheral magnetic stimulation Stroke Upper limb Motor function Rehabilitation |
| url | https://doi.org/10.1186/s12984-024-01341-w |
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