Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

The intrahelical salt bridge between E/D(3.49) and R(3.50) within the E/DRY motif on helix 3 (H3) and the interhelical hydrogen bonding between the E/DRY and residues on H6 are thought to be critical in stabilizing the class A G protein-coupled receptors in their inactive state. Removal of these int...

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Bibliographic Details
Main Authors: Valérie Capra, Marta Busnelli, Alessandro Perenna, Manuela Ambrosio, Maria Rosa Accomazzo, Celine Galés, Bice Chini, G Enrico Rovati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3610872?pdf=render

Internet

http://europepmc.org/articles/PMC3610872?pdf=render

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