Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.
The intrahelical salt bridge between E/D(3.49) and R(3.50) within the E/DRY motif on helix 3 (H3) and the interhelical hydrogen bonding between the E/DRY and residues on H6 are thought to be critical in stabilizing the class A G protein-coupled receptors in their inactive state. Removal of these int...
| Main Authors: | , , , , , , , |
|---|---|
| 格式: | Article |
| 語言: | English |
| 出版: |
Public Library of Science (PLoS)
2013-01-01
|
| 叢編: | PLoS ONE |
| 在線閱讀: | http://europepmc.org/articles/PMC3610872?pdf=render |