Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury
Acute kidney injury (AKI) has impacted a heavy burden on global healthcare system with a high morbidity and mortality in both hospitalized and critically ill patients. However, there are still some shortcomings in clinical approaches for the disease to date, appealing for an earlier recognition and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/6/3093 |
| _version_ | 1797470888633827328 |
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| author | Yiwen Ying Qian Tang Da Han Shan Mou |
| author_facet | Yiwen Ying Qian Tang Da Han Shan Mou |
| author_sort | Yiwen Ying |
| collection | DOAJ |
| description | Acute kidney injury (AKI) has impacted a heavy burden on global healthcare system with a high morbidity and mortality in both hospitalized and critically ill patients. However, there are still some shortcomings in clinical approaches for the disease to date, appealing for an earlier recognition and specific intervention to improve long-term outcomes. In the past decades, owing to the predictable base-pairing rule and highly modifiable characteristics, nucleic acids have already become significant biomaterials for nanostructure and nanodevice fabrication, which is known as nucleic acid nanotechnology. In particular, its excellent programmability and biocompatibility have further promoted its intersection with medical challenges. Lately, there have been an influx of research connecting nucleic acid nanotechnology with the clinical needs for renal diseases, especially AKI. In this review, we begin with the diagnostics of AKI based on nucleic acid nanotechnology with a highlight on aptamer- and probe-functionalized detection. Then, recently developed nanoscale nucleic acid therapeutics towards AKI will be fully elucidated. Furthermore, the strengths and limitations will be summarized, envisioning a wiser and wider application of nucleic acid nanotechnology in the future of AKI. |
| first_indexed | 2024-03-09T19:42:18Z |
| format | Article |
| id | doaj.art-4c39ef060d0f42f6b243101c4e3d1650 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:42:18Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4c39ef060d0f42f6b243101c4e3d16502023-11-24T01:32:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236309310.3390/ijms23063093Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney InjuryYiwen Ying0Qian Tang1Da Han2Shan Mou3Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, ChinaInstitute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, ChinaInstitute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, ChinaAcute kidney injury (AKI) has impacted a heavy burden on global healthcare system with a high morbidity and mortality in both hospitalized and critically ill patients. However, there are still some shortcomings in clinical approaches for the disease to date, appealing for an earlier recognition and specific intervention to improve long-term outcomes. In the past decades, owing to the predictable base-pairing rule and highly modifiable characteristics, nucleic acids have already become significant biomaterials for nanostructure and nanodevice fabrication, which is known as nucleic acid nanotechnology. In particular, its excellent programmability and biocompatibility have further promoted its intersection with medical challenges. Lately, there have been an influx of research connecting nucleic acid nanotechnology with the clinical needs for renal diseases, especially AKI. In this review, we begin with the diagnostics of AKI based on nucleic acid nanotechnology with a highlight on aptamer- and probe-functionalized detection. Then, recently developed nanoscale nucleic acid therapeutics towards AKI will be fully elucidated. Furthermore, the strengths and limitations will be summarized, envisioning a wiser and wider application of nucleic acid nanotechnology in the future of AKI.https://www.mdpi.com/1422-0067/23/6/3093nucleic acid nanotechnologyAKIaptamerframework nucleic acidsdiagnosistargeted therapy |
| spellingShingle | Yiwen Ying Qian Tang Da Han Shan Mou Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury International Journal of Molecular Sciences nucleic acid nanotechnology AKI aptamer framework nucleic acids diagnosis targeted therapy |
| title | Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury |
| title_full | Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury |
| title_fullStr | Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury |
| title_full_unstemmed | Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury |
| title_short | Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury |
| title_sort | nucleic acid nanotechnology for diagnostics and therapeutics in acute kidney injury |
| topic | nucleic acid nanotechnology AKI aptamer framework nucleic acids diagnosis targeted therapy |
| url | https://www.mdpi.com/1422-0067/23/6/3093 |
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