Significance of Susceptible Gene Expression Profiles in Nasal Polyposis
Nasal polyposis (NP) is a common chronic inflammatory disease of the rhinosinus mucosa and a complex disease with strong genetic and environmental components. During the past 10 to 20 yr, many studies have been performed to determine differential gene expression profiles between NP and normal nasal...
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2008-12-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-1-177.pdf |
| _version_ | 1819179607881940992 |
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| author | De Yun Wang |
| author_facet | De Yun Wang |
| author_sort | De Yun Wang |
| collection | DOAJ |
| description | Nasal polyposis (NP) is a common chronic inflammatory disease of the rhinosinus mucosa and a complex disease with strong genetic and environmental components. During the past 10 to 20 yr, many studies have been performed to determine differential gene expression profiles between NP and normal nasal tissues, in order to identify susceptible genes that are associated with NP-related traits. Despite achievement in the identification of candidate genes and their associated pathogenic pathways, the large challenges remain as the genetic and molecular alterations required for its development and progression are still unclear. Therefore, the development of novel, powerful tools for gene discovery, and a closer integration of genetics and medical biology would provide valuable insight into the pathogenesis of NP. |
| first_indexed | 2024-12-22T22:01:08Z |
| format | Article |
| id | doaj.art-4c3cab92fd8a4e5f9ec1e0985c0bae03 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-22T22:01:08Z |
| publishDate | 2008-12-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-4c3cab92fd8a4e5f9ec1e0985c0bae032022-12-21T18:11:06ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202008-12-011417718310.3342/ceo.2008.1.4.17718Significance of Susceptible Gene Expression Profiles in Nasal PolyposisDe Yun Wang0Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.Nasal polyposis (NP) is a common chronic inflammatory disease of the rhinosinus mucosa and a complex disease with strong genetic and environmental components. During the past 10 to 20 yr, many studies have been performed to determine differential gene expression profiles between NP and normal nasal tissues, in order to identify susceptible genes that are associated with NP-related traits. Despite achievement in the identification of candidate genes and their associated pathogenic pathways, the large challenges remain as the genetic and molecular alterations required for its development and progression are still unclear. Therefore, the development of novel, powerful tools for gene discovery, and a closer integration of genetics and medical biology would provide valuable insight into the pathogenesis of NP.http://www.e-ceo.org/upload/pdf/ceo-1-177.pdfNasal polyposisGeneticsGene expression profilePathogenesis and pathophysiologySusceptible genes and pathways |
| spellingShingle | De Yun Wang Significance of Susceptible Gene Expression Profiles in Nasal Polyposis Clinical and Experimental Otorhinolaryngology Nasal polyposis Genetics Gene expression profile Pathogenesis and pathophysiology Susceptible genes and pathways |
| title | Significance of Susceptible Gene Expression Profiles in Nasal Polyposis |
| title_full | Significance of Susceptible Gene Expression Profiles in Nasal Polyposis |
| title_fullStr | Significance of Susceptible Gene Expression Profiles in Nasal Polyposis |
| title_full_unstemmed | Significance of Susceptible Gene Expression Profiles in Nasal Polyposis |
| title_short | Significance of Susceptible Gene Expression Profiles in Nasal Polyposis |
| title_sort | significance of susceptible gene expression profiles in nasal polyposis |
| topic | Nasal polyposis Genetics Gene expression profile Pathogenesis and pathophysiology Susceptible genes and pathways |
| url | http://www.e-ceo.org/upload/pdf/ceo-1-177.pdf |
| work_keys_str_mv | AT deyunwang significanceofsusceptiblegeneexpressionprofilesinnasalpolyposis |