Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids

Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids

The in vivo-relevant phenotype of 3D liver spheroids allows for long-term studies of, e.g., novel mechanisms of chronic drug-induced liver toxicity. Using this system, we present a novel drug-induced stress response in human and murine hepatocyte spheroids, wherein long slender filaments form after...

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Bibliographic Details
Main Authors: Chris S. Pridgeon, Dian P. Bolhuis, Filip Milosavljević, Marina Manojlović, Ákos Végvári, Massimiliano Gaetani, Marin M. Jukić, Magnus Ingelman-Sundberg
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
hepatocytes
spheroids
thorns
hepatotoxicity
keratins
3D culture
Online Access:https://www.mdpi.com/2073-4409/11/10/1597

Internet

https://www.mdpi.com/2073-4409/11/10/1597

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