The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures
Abstract Background Chronic Endometritis (CE) is a subtle pathology, likely infectious in most cases, with a negative impact on the female fertility, but often overlooked even among fertility specialists. The purpose of the study is to demonstrate the predominant infectious nature of CE and to find...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-022-02128-8 |
| _version_ | 1828264932819337216 |
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| author | Mihai Luncan Anca Huniadi Erika Bimbo-Szuhai Mihai Botea Ioana Zaha Liana Stefan Corina Beiusanu Dana Romanescu Annamaria Pallag Alin Bodog Laurean Ovidiu Pop Mircea Ioan Șandor |
| author_facet | Mihai Luncan Anca Huniadi Erika Bimbo-Szuhai Mihai Botea Ioana Zaha Liana Stefan Corina Beiusanu Dana Romanescu Annamaria Pallag Alin Bodog Laurean Ovidiu Pop Mircea Ioan Șandor |
| author_sort | Mihai Luncan |
| collection | DOAJ |
| description | Abstract Background Chronic Endometritis (CE) is a subtle pathology, likely infectious in most cases, with a negative impact on the female fertility, but often overlooked even among fertility specialists. The purpose of the study is to demonstrate the predominant infectious nature of CE and to find the best therapeutic option by comparing the results of oral antibiotic therapy versus intrauterine antibiotic infusion in patients with CE undergoing IVF procedures. The objective was to compare the cure rate of CE—defined as the percentage of patients without CE at the test of cure, between the two groups and, the hysteroscopic aspect with the positive CD 138 staining. Methods This was a prospective, case—control study that took place in a single university fertility clinic, in Oradea, Romania and included 57 patients with CE divided into 2 groups: orally administered antibiotics group who received a combination of antibiotics compared to intrauterine infusion group who received intrauterine infusion of antibiotic. Chronic Endometritis was diagnosed through hysteroscopy and immunohistochemistry for CD 138. Patients in both groups were tested for CE twice to evaluate the cure rate after oral combination antibiotic therapy versus intrauterine infusion of antibiotic. Results Out of 115 patients with endometrial biopsies 57 tested positive for CE, with a 49.6% chronic endometritis prevalence. Among the group that was administered oral antibiotics, 11 patients (45.83%) experienced CE resolution after triple antibiotic therapy. Of the intrauterine infusion group, 25 patients (89.29%) presented negative results (p 0.0020). The normal hysteroscopic aspect had a similar prevalence in the patients with immunohistochemical positive and negative CD 138. Conclusions Our study demonstrated the effectiveness and superiority of intrauterine antibiotic infusion over the use of oral combination antibiotic therapy for CE cure. Trial Registration: ISRCTN17542620/14.09.2022. |
| first_indexed | 2024-04-13T04:31:11Z |
| format | Article |
| id | doaj.art-4c41c9f0ef5147fa93d7b06754fcf124 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-04-13T04:31:11Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-4c41c9f0ef5147fa93d7b06754fcf1242022-12-22T03:02:18ZengBMCBMC Women's Health1472-68742022-12-012211910.1186/s12905-022-02128-8The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) proceduresMihai Luncan0Anca Huniadi1Erika Bimbo-Szuhai2Mihai Botea3Ioana Zaha4Liana Stefan5Corina Beiusanu6Dana Romanescu7Annamaria Pallag8Alin Bodog9Laurean Ovidiu Pop10Mircea Ioan Șandor11Faculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaFaculty of Medicine and Pharmacy, University of OradeaAbstract Background Chronic Endometritis (CE) is a subtle pathology, likely infectious in most cases, with a negative impact on the female fertility, but often overlooked even among fertility specialists. The purpose of the study is to demonstrate the predominant infectious nature of CE and to find the best therapeutic option by comparing the results of oral antibiotic therapy versus intrauterine antibiotic infusion in patients with CE undergoing IVF procedures. The objective was to compare the cure rate of CE—defined as the percentage of patients without CE at the test of cure, between the two groups and, the hysteroscopic aspect with the positive CD 138 staining. Methods This was a prospective, case—control study that took place in a single university fertility clinic, in Oradea, Romania and included 57 patients with CE divided into 2 groups: orally administered antibiotics group who received a combination of antibiotics compared to intrauterine infusion group who received intrauterine infusion of antibiotic. Chronic Endometritis was diagnosed through hysteroscopy and immunohistochemistry for CD 138. Patients in both groups were tested for CE twice to evaluate the cure rate after oral combination antibiotic therapy versus intrauterine infusion of antibiotic. Results Out of 115 patients with endometrial biopsies 57 tested positive for CE, with a 49.6% chronic endometritis prevalence. Among the group that was administered oral antibiotics, 11 patients (45.83%) experienced CE resolution after triple antibiotic therapy. Of the intrauterine infusion group, 25 patients (89.29%) presented negative results (p 0.0020). The normal hysteroscopic aspect had a similar prevalence in the patients with immunohistochemical positive and negative CD 138. Conclusions Our study demonstrated the effectiveness and superiority of intrauterine antibiotic infusion over the use of oral combination antibiotic therapy for CE cure. Trial Registration: ISRCTN17542620/14.09.2022.https://doi.org/10.1186/s12905-022-02128-8Chronic endometritisHysteroscopyImmunohistochemistry for CD 138Intrauterine antibiotic infusionOral antibiotic therapy |
| spellingShingle | Mihai Luncan Anca Huniadi Erika Bimbo-Szuhai Mihai Botea Ioana Zaha Liana Stefan Corina Beiusanu Dana Romanescu Annamaria Pallag Alin Bodog Laurean Ovidiu Pop Mircea Ioan Șandor The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures BMC Women's Health Chronic endometritis Hysteroscopy Immunohistochemistry for CD 138 Intrauterine antibiotic infusion Oral antibiotic therapy |
| title | The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures |
| title_full | The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures |
| title_fullStr | The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures |
| title_full_unstemmed | The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures |
| title_short | The effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during IVF (in vitro fertilization) procedures |
| title_sort | effectiveness of intrauterine antibiotic infusion versus oral antibiotic therapy in the treatment of chronic endometritis in patients during ivf in vitro fertilization procedures |
| topic | Chronic endometritis Hysteroscopy Immunohistochemistry for CD 138 Intrauterine antibiotic infusion Oral antibiotic therapy |
| url | https://doi.org/10.1186/s12905-022-02128-8 |
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