Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia.
<h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality.<h4>Objective</h4>To identify the factors associa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0260169 |
| _version_ | 1819176011180277760 |
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| author | Jorge Enrique Machado-Alba Luis Fernando Valladales-Restrepo Manuel Enrique Machado-Duque Andrés Gaviria-Mendoza Nicolás Sánchez-Ramírez Andrés Felipe Usma-Valencia Esteban Rodríguez-Martínez Eliana Rengifo-Franco Víctor Hugo Forero-Supelano Diego Mauricio Gómez-Ramirez Alejandra Sabogal-Ortiz |
| author_facet | Jorge Enrique Machado-Alba Luis Fernando Valladales-Restrepo Manuel Enrique Machado-Duque Andrés Gaviria-Mendoza Nicolás Sánchez-Ramírez Andrés Felipe Usma-Valencia Esteban Rodríguez-Martínez Eliana Rengifo-Franco Víctor Hugo Forero-Supelano Diego Mauricio Gómez-Ramirez Alejandra Sabogal-Ortiz |
| author_sort | Jorge Enrique Machado-Alba |
| collection | DOAJ |
| description | <h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality.<h4>Objective</h4>To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia.<h4>Methods</h4>This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05).<h4>Results</h4>A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99-16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002-1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16-9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09-3.90). The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66-5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41-11.78), admitted to the ICU (OR:6.31; 95%CI:3.63-10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002-1.35).<h4>Conclusions</h4>Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis. |
| first_indexed | 2024-12-22T21:03:58Z |
| format | Article |
| id | doaj.art-4c4287c6cbbd493a9fffb4f2ffbe63a8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T21:03:58Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4c4287c6cbbd493a9fffb4f2ffbe63a82022-12-21T18:12:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611e026016910.1371/journal.pone.0260169Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia.Jorge Enrique Machado-AlbaLuis Fernando Valladales-RestrepoManuel Enrique Machado-DuqueAndrés Gaviria-MendozaNicolás Sánchez-RamírezAndrés Felipe Usma-ValenciaEsteban Rodríguez-MartínezEliana Rengifo-FrancoVíctor Hugo Forero-SupelanoDiego Mauricio Gómez-RamirezAlejandra Sabogal-Ortiz<h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality.<h4>Objective</h4>To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia.<h4>Methods</h4>This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05).<h4>Results</h4>A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99-16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002-1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16-9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09-3.90). The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66-5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41-11.78), admitted to the ICU (OR:6.31; 95%CI:3.63-10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002-1.35).<h4>Conclusions</h4>Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis.https://doi.org/10.1371/journal.pone.0260169 |
| spellingShingle | Jorge Enrique Machado-Alba Luis Fernando Valladales-Restrepo Manuel Enrique Machado-Duque Andrés Gaviria-Mendoza Nicolás Sánchez-Ramírez Andrés Felipe Usma-Valencia Esteban Rodríguez-Martínez Eliana Rengifo-Franco Víctor Hugo Forero-Supelano Diego Mauricio Gómez-Ramirez Alejandra Sabogal-Ortiz Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. PLoS ONE |
| title | Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. |
| title_full | Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. |
| title_fullStr | Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. |
| title_full_unstemmed | Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. |
| title_short | Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. |
| title_sort | factors associated with admission to the intensive care unit and mortality in patients with covid 19 colombia |
| url | https://doi.org/10.1371/journal.pone.0260169 |
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