New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir
The combination therapy of ledipasvir/sofosbuvir was approved by the Food and Drug Administration in 2014 for the treatment of chronic hepatitis C. Although hyperglycemia is not well known to occur with its use, we present 2 cases of new-onset diabetes mellitus and a review of the literature suggest...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-12-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709615623300 |
| _version_ | 1828266593892696064 |
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| author | Resmi Premji MD Nira Roopnarinesingh MD Nazia Qazi MD Eric S Nylen MD |
| author_facet | Resmi Premji MD Nira Roopnarinesingh MD Nazia Qazi MD Eric S Nylen MD |
| author_sort | Resmi Premji MD |
| collection | DOAJ |
| description | The combination therapy of ledipasvir/sofosbuvir was approved by the Food and Drug Administration in 2014 for the treatment of chronic hepatitis C. Although hyperglycemia is not well known to occur with its use, we present 2 cases of new-onset diabetes mellitus and a review of the literature suggesting an adverse event association. In the first patient with HIV, we postulate that ledipasvir/sofosbuvir increased the levels of tenofovir and thereby potentiated hyperglycemia. In the second case of a patient with prediabetes, ledipasvir/sofosbuvir appeared to increase insulin resistance. A literature review further supported an association of hyperglycemia and the use of ledipasvir/sofosbuvir. Hence, clinicians should be cautious about worsening of glucose intolerance, and more studies are warranted to explore the underlying mechanism. |
| first_indexed | 2024-04-13T04:55:10Z |
| format | Article |
| id | doaj.art-4c43c9ca2048400c9c850dd74d5e1b8e |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-04-13T04:55:10Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-4c43c9ca2048400c9c850dd74d5e1b8e2022-12-22T03:01:32ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962015-12-01310.1177/232470961562330010.1177_2324709615623300New-Onset Diabetes Mellitus With Exposure to Ledipasvir and SofosbuvirResmi Premji MD0Nira Roopnarinesingh MD1Nazia Qazi MD2Eric S Nylen MD3George Washington University Hospital, Washington, DC, USAGeorge Washington University Hospital, Washington, DC, USAVA Medical Center, Washington, DC, USAVA Medical Center, Washington, DC, USAThe combination therapy of ledipasvir/sofosbuvir was approved by the Food and Drug Administration in 2014 for the treatment of chronic hepatitis C. Although hyperglycemia is not well known to occur with its use, we present 2 cases of new-onset diabetes mellitus and a review of the literature suggesting an adverse event association. In the first patient with HIV, we postulate that ledipasvir/sofosbuvir increased the levels of tenofovir and thereby potentiated hyperglycemia. In the second case of a patient with prediabetes, ledipasvir/sofosbuvir appeared to increase insulin resistance. A literature review further supported an association of hyperglycemia and the use of ledipasvir/sofosbuvir. Hence, clinicians should be cautious about worsening of glucose intolerance, and more studies are warranted to explore the underlying mechanism.https://doi.org/10.1177/2324709615623300 |
| spellingShingle | Resmi Premji MD Nira Roopnarinesingh MD Nazia Qazi MD Eric S Nylen MD New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir Journal of Investigative Medicine High Impact Case Reports |
| title | New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir |
| title_full | New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir |
| title_fullStr | New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir |
| title_full_unstemmed | New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir |
| title_short | New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir |
| title_sort | new onset diabetes mellitus with exposure to ledipasvir and sofosbuvir |
| url | https://doi.org/10.1177/2324709615623300 |
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