A New Cytotoxic Pregnanone from Calotropis gigantea
A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic my...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2008-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/13/12/3033/ |
| _version_ | 1828471477389754368 |
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| author | Mao-Yuan Wang Zhu-Nian Wang Wen-Li Mei Zhuang Han Hao-Fu Dai |
| author_facet | Mao-Yuan Wang Zhu-Nian Wang Wen-Li Mei Zhuang Han Hao-Fu Dai |
| author_sort | Mao-Yuan Wang |
| collection | DOAJ |
| description | A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines. |
| first_indexed | 2024-12-11T05:13:07Z |
| format | Article |
| id | doaj.art-4c44c16dd8c44d11bcd76ce6128f46a4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T05:13:07Z |
| publishDate | 2008-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4c44c16dd8c44d11bcd76ce6128f46a42022-12-22T01:19:53ZengMDPI AGMolecules1420-30492008-12-0113123033303910.3390/molecules13123033A New Cytotoxic Pregnanone from Calotropis giganteaMao-Yuan WangZhu-Nian WangWen-Li MeiZhuang HanHao-Fu DaiA new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.http://www.mdpi.com/1420-3049/13/12/3033/Calotropis gigantea L.CalotroponeCytotoxicity |
| spellingShingle | Mao-Yuan Wang Zhu-Nian Wang Wen-Li Mei Zhuang Han Hao-Fu Dai A New Cytotoxic Pregnanone from Calotropis gigantea Molecules Calotropis gigantea L. Calotropone Cytotoxicity |
| title | A New Cytotoxic Pregnanone from Calotropis gigantea |
| title_full | A New Cytotoxic Pregnanone from Calotropis gigantea |
| title_fullStr | A New Cytotoxic Pregnanone from Calotropis gigantea |
| title_full_unstemmed | A New Cytotoxic Pregnanone from Calotropis gigantea |
| title_short | A New Cytotoxic Pregnanone from Calotropis gigantea |
| title_sort | new cytotoxic pregnanone from calotropis gigantea |
| topic | Calotropis gigantea L. Calotropone Cytotoxicity |
| url | http://www.mdpi.com/1420-3049/13/12/3033/ |
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