Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis

Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis

Renal fibrosis is a hallmark of diabetic nephropathy (DN) and is characterized by an epithelial-to-mesenchymal transition (EMT) program and aberrant glycolysis. The underlying mechanisms of renal fibrosis are still poorly understood, and existing treatments are only marginally effective. Therefore,...

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Bibliographic Details
Main Authors:	Chin-Wei Kuo, Dong-Hao Chen, Ming-Tsun Tsai, Chih-Ching Lin, Hsiao-Wei Cheng, Yeou-Guang Tsay, Hsiang-Tsui Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Medicine
Subjects:	renal fibrosis acrolein pyruvate kinase M2 hypoxia-inducible factor 1-alpha hydralazine carnosine
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1151359/full

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