Perspectives of pharmacological intervention promoting liver regeneration
Effective drug therapy promoting liver regeneration is a challenging goal in pharmacotherapy of liver diseases. Several plant phytochemicals recommended in traditional medicine from over hundred plants have been investigated for its use in various liver disorders. Regeneration of injured liver depen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Applied Sciences in Tarnow, Poland
2018-03-01
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| Series: | Health Promotion & Physical Activity |
| Subjects: | |
| Online Access: | https://journals.anstar.edu.pl/index.php/hppa/article/view/96 |
| _version_ | 1797777628582641664 |
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| author | Irina Danilova Hanna Kalota Musa Abidov |
| author_facet | Irina Danilova Hanna Kalota Musa Abidov |
| author_sort | Irina Danilova |
| collection | DOAJ |
| description | Effective drug therapy promoting liver regeneration is a challenging goal in pharmacotherapy of liver diseases. Several plant phytochemicals recommended in traditional medicine from over hundred plants have been investigated for its use in various liver disorders. Regeneration of injured liver depend on a proliferative potential of mature hepatocytes as well as different subsets of intrahepatic and extrahepatic stem/progenitor cells. In clinical trials a stem cell therapy resulted in a limited improvement of liver functions. Animal studies have demonstrated the involvement of bone marrow-derived stem/progenitor cells in liver regeneration. For this reason, the pharmacological activation of endogenous stem cells and pharmacological control of macrophage phenotypic polarization could be an effective method of mobilizing progenitor cells to injured liver. |
| first_indexed | 2024-03-12T23:07:30Z |
| format | Article |
| id | doaj.art-4c4605a94124409c8dc4854eae60de69 |
| institution | Directory Open Access Journal |
| issn | 2544-9117 |
| language | English |
| last_indexed | 2024-03-12T23:07:30Z |
| publishDate | 2018-03-01 |
| publisher | University of Applied Sciences in Tarnow, Poland |
| record_format | Article |
| series | Health Promotion & Physical Activity |
| spelling | doaj.art-4c4605a94124409c8dc4854eae60de692023-07-18T12:14:54ZengUniversity of Applied Sciences in Tarnow, PolandHealth Promotion & Physical Activity2544-91172018-03-01211410.5604/01.3001.0012.137296Perspectives of pharmacological intervention promoting liver regenerationIrina Danilova0Hanna Kalota1Musa Abidov2Institute of Immunology and Physiology of the Ural Branch of the RAS, Ural Federal University named after the first President of Russia B.N. Yeltsin, Yekaterinburg, Russian FederationCity Clinic, Warszawa, PolandInstitute of Immunopathology and Preventive Medicine, Lublana, SloveniaEffective drug therapy promoting liver regeneration is a challenging goal in pharmacotherapy of liver diseases. Several plant phytochemicals recommended in traditional medicine from over hundred plants have been investigated for its use in various liver disorders. Regeneration of injured liver depend on a proliferative potential of mature hepatocytes as well as different subsets of intrahepatic and extrahepatic stem/progenitor cells. In clinical trials a stem cell therapy resulted in a limited improvement of liver functions. Animal studies have demonstrated the involvement of bone marrow-derived stem/progenitor cells in liver regeneration. For this reason, the pharmacological activation of endogenous stem cells and pharmacological control of macrophage phenotypic polarization could be an effective method of mobilizing progenitor cells to injured liver.https://journals.anstar.edu.pl/index.php/hppa/article/view/96liver regenerationstem cells therapymacrophage reprogrammingpharmacotherapy of liver diseases |
| spellingShingle | Irina Danilova Hanna Kalota Musa Abidov Perspectives of pharmacological intervention promoting liver regeneration Health Promotion & Physical Activity liver regeneration stem cells therapy macrophage reprogramming pharmacotherapy of liver diseases |
| title | Perspectives of pharmacological intervention promoting liver regeneration |
| title_full | Perspectives of pharmacological intervention promoting liver regeneration |
| title_fullStr | Perspectives of pharmacological intervention promoting liver regeneration |
| title_full_unstemmed | Perspectives of pharmacological intervention promoting liver regeneration |
| title_short | Perspectives of pharmacological intervention promoting liver regeneration |
| title_sort | perspectives of pharmacological intervention promoting liver regeneration |
| topic | liver regeneration stem cells therapy macrophage reprogramming pharmacotherapy of liver diseases |
| url | https://journals.anstar.edu.pl/index.php/hppa/article/view/96 |
| work_keys_str_mv | AT irinadanilova perspectivesofpharmacologicalinterventionpromotingliverregeneration AT hannakalota perspectivesofpharmacologicalinterventionpromotingliverregeneration AT musaabidov perspectivesofpharmacologicalinterventionpromotingliverregeneration |