Case report: nosocomial fungemia caused by Candida diddensiae
Abstract Background Candida diddensiae, a yeast found in olive oil, is considered non-pathogenic to humans. Here, we describe the first case of fungemia caused by C. diddensiae in a hospitalized patient with underlying diseases. Case presentation A 62-year-old woman was admitted because of multiple...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05095-3 |
| _version_ | 1811310107708882944 |
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| author | Seong Eun Kim Sook In Jung Kyung-Hwa Park Yong Jun Choi Eun Jeong Won Jong Hee Shin |
| author_facet | Seong Eun Kim Sook In Jung Kyung-Hwa Park Yong Jun Choi Eun Jeong Won Jong Hee Shin |
| author_sort | Seong Eun Kim |
| collection | DOAJ |
| description | Abstract Background Candida diddensiae, a yeast found in olive oil, is considered non-pathogenic to humans. Here, we describe the first case of fungemia caused by C. diddensiae in a hospitalized patient with underlying diseases. Case presentation A 62-year-old woman was admitted because of multiple contusions due to repeated falls and generalized weakness. She presented with chronic leukopenia due to systemic lupus erythematosus, and multiple cranial nerve neuropathies due to a recurring chordoma. She was given a lipid emulsion containing total parenteral nutrition (TPN) starting on the day of admission. Broad-spectrum antibiotics had been administered during her last hospital stay and from day 8 of this hospitalization. However, no central venous catheter was used during this hospital stay. Blood cultures obtained on hospital days 17, 23, and 24 yielded the same yeast, which was identified as C. diddensiae via sequence analyses of the internal transcribed spacer region and D1/D2 regions of the 26S ribosomal DNA of the rRNA gene. In vitro susceptibility testing showed that the minimum inhibitory concentration of fluconazole for all isolates was 8 μg/mL. On day 23, TPN was discontinued and fluconazole therapy was started. Blood cultures obtained on day 26 were negative. The fluconazole therapy was replaced with micafungin on day 26 and the patient exhibited improvements. Conclusion The use of lipid TPN may potentially contribute to the occurrence of nosocomial fungemia by C. diddensiae, an unusual Candida species. |
| first_indexed | 2024-04-13T09:53:41Z |
| format | Article |
| id | doaj.art-4c4661bdbb6247c2b71d09f3f295cb42 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T09:53:41Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-4c4661bdbb6247c2b71d09f3f295cb422022-12-22T02:51:31ZengBMCBMC Infectious Diseases1471-23342020-05-012011410.1186/s12879-020-05095-3Case report: nosocomial fungemia caused by Candida diddensiaeSeong Eun Kim0Sook In Jung1Kyung-Hwa Park2Yong Jun Choi3Eun Jeong Won4Jong Hee Shin5Department of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Laboratory Medicine, Chonnam National University Medical SchoolDepartment of Laboratory Medicine, Chonnam National University Medical SchoolDepartment of Laboratory Medicine, Chonnam National University Medical SchoolAbstract Background Candida diddensiae, a yeast found in olive oil, is considered non-pathogenic to humans. Here, we describe the first case of fungemia caused by C. diddensiae in a hospitalized patient with underlying diseases. Case presentation A 62-year-old woman was admitted because of multiple contusions due to repeated falls and generalized weakness. She presented with chronic leukopenia due to systemic lupus erythematosus, and multiple cranial nerve neuropathies due to a recurring chordoma. She was given a lipid emulsion containing total parenteral nutrition (TPN) starting on the day of admission. Broad-spectrum antibiotics had been administered during her last hospital stay and from day 8 of this hospitalization. However, no central venous catheter was used during this hospital stay. Blood cultures obtained on hospital days 17, 23, and 24 yielded the same yeast, which was identified as C. diddensiae via sequence analyses of the internal transcribed spacer region and D1/D2 regions of the 26S ribosomal DNA of the rRNA gene. In vitro susceptibility testing showed that the minimum inhibitory concentration of fluconazole for all isolates was 8 μg/mL. On day 23, TPN was discontinued and fluconazole therapy was started. Blood cultures obtained on day 26 were negative. The fluconazole therapy was replaced with micafungin on day 26 and the patient exhibited improvements. Conclusion The use of lipid TPN may potentially contribute to the occurrence of nosocomial fungemia by C. diddensiae, an unusual Candida species.http://link.springer.com/article/10.1186/s12879-020-05095-3Candida diddensiaeFungemiaLeukopeniaMalignancyTotal parenteral nutrition |
| spellingShingle | Seong Eun Kim Sook In Jung Kyung-Hwa Park Yong Jun Choi Eun Jeong Won Jong Hee Shin Case report: nosocomial fungemia caused by Candida diddensiae BMC Infectious Diseases Candida diddensiae Fungemia Leukopenia Malignancy Total parenteral nutrition |
| title | Case report: nosocomial fungemia caused by Candida diddensiae |
| title_full | Case report: nosocomial fungemia caused by Candida diddensiae |
| title_fullStr | Case report: nosocomial fungemia caused by Candida diddensiae |
| title_full_unstemmed | Case report: nosocomial fungemia caused by Candida diddensiae |
| title_short | Case report: nosocomial fungemia caused by Candida diddensiae |
| title_sort | case report nosocomial fungemia caused by candida diddensiae |
| topic | Candida diddensiae Fungemia Leukopenia Malignancy Total parenteral nutrition |
| url | http://link.springer.com/article/10.1186/s12879-020-05095-3 |
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