AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up
Turner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50% of girls with a mosaic 45...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1173600/full |
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| author | Casper P. Hagen Casper P. Hagen Margit Bistrup Fischer Margit Bistrup Fischer Gylli Mola Gylli Mola Theis Bech Mikkelsen Theis Bech Mikkelsen Line Hartvig Cleemann Line Hartvig Cleemann Claus Højbjerg Gravholt Claus Højbjerg Gravholt Mette H. Viuff Anders Juul Anders Juul Anders Juul Anette Tønnes Pedersen Katharina Maria Main Katharina Maria Main Katharina Maria Main |
| author_facet | Casper P. Hagen Casper P. Hagen Margit Bistrup Fischer Margit Bistrup Fischer Gylli Mola Gylli Mola Theis Bech Mikkelsen Theis Bech Mikkelsen Line Hartvig Cleemann Line Hartvig Cleemann Claus Højbjerg Gravholt Claus Højbjerg Gravholt Mette H. Viuff Anders Juul Anders Juul Anders Juul Anette Tønnes Pedersen Katharina Maria Main Katharina Maria Main Katharina Maria Main |
| author_sort | Casper P. Hagen |
| collection | DOAJ |
| description | Turner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50% of girls with a mosaic 45, X/46, XX karyotype may enter puberty spontaneously, but only 5-10% of women with TS achieve pregnancy without egg donation. In this review, we will evaluate the clinical use of markers of ovarian function in TS patients. Based on longitudinal studies of serum concentrations of reproductive hormones as well as ovarian morphology in healthy females and patients with TS, we will evaluate how they can be applied in a clinical setting. This is important when counseling patients and their families about future ovarian function essential for pubertal development and fertility. Furthermore, we will report on 20 years of experience of transition from pediatric to gynecological and adult endocrinological care in our center at Rigshospitalet, Copenhagen, Denmark. |
| first_indexed | 2024-03-13T02:31:01Z |
| format | Article |
| id | doaj.art-4c4718a922244133931bce82144a476a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T02:31:01Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4c4718a922244133931bce82144a476a2023-06-29T15:30:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11736001173600AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow upCasper P. Hagen0Casper P. Hagen1Margit Bistrup Fischer2Margit Bistrup Fischer3Gylli Mola4Gylli Mola5Theis Bech Mikkelsen6Theis Bech Mikkelsen7Line Hartvig Cleemann8Line Hartvig Cleemann9Claus Højbjerg Gravholt10Claus Højbjerg Gravholt11Mette H. Viuff12Anders Juul13Anders Juul14Anders Juul15Anette Tønnes Pedersen16Katharina Maria Main17Katharina Maria Main18Katharina Maria Main19Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, DenmarkDepartment of Diabetes and Endocrine Diseases, Aarhus University Hospital, Aarhus, DenmarkDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, DenmarkDepartment of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkDepartment of Gynecology, The Fertility Clinic, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkDepartment of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkInternational Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkTurner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50% of girls with a mosaic 45, X/46, XX karyotype may enter puberty spontaneously, but only 5-10% of women with TS achieve pregnancy without egg donation. In this review, we will evaluate the clinical use of markers of ovarian function in TS patients. Based on longitudinal studies of serum concentrations of reproductive hormones as well as ovarian morphology in healthy females and patients with TS, we will evaluate how they can be applied in a clinical setting. This is important when counseling patients and their families about future ovarian function essential for pubertal development and fertility. Furthermore, we will report on 20 years of experience of transition from pediatric to gynecological and adult endocrinological care in our center at Rigshospitalet, Copenhagen, Denmark.https://www.frontiersin.org/articles/10.3389/fendo.2023.1173600/fullovarian functionfertility preservationturner syndromeanti mullerian hormone (AMH)FSH (Follicle Stimulating Hormone)inhibin B |
| spellingShingle | Casper P. Hagen Casper P. Hagen Margit Bistrup Fischer Margit Bistrup Fischer Gylli Mola Gylli Mola Theis Bech Mikkelsen Theis Bech Mikkelsen Line Hartvig Cleemann Line Hartvig Cleemann Claus Højbjerg Gravholt Claus Højbjerg Gravholt Mette H. Viuff Anders Juul Anders Juul Anders Juul Anette Tønnes Pedersen Katharina Maria Main Katharina Maria Main Katharina Maria Main AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up Frontiers in Endocrinology ovarian function fertility preservation turner syndrome anti mullerian hormone (AMH) FSH (Follicle Stimulating Hormone) inhibin B |
| title | AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up |
| title_full | AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up |
| title_fullStr | AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up |
| title_full_unstemmed | AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up |
| title_short | AMH and other markers of ovarian function in patients with Turner syndrome – a single center experience of transition from pediatric to gynecological follow up |
| title_sort | amh and other markers of ovarian function in patients with turner syndrome a single center experience of transition from pediatric to gynecological follow up |
| topic | ovarian function fertility preservation turner syndrome anti mullerian hormone (AMH) FSH (Follicle Stimulating Hormone) inhibin B |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1173600/full |
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