Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives
Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pathologists & the Korean Society for Cytopathology
2017-05-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2017-04-09.pdf |
| _version_ | 1828239872728498176 |
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| author | Yoon Kyung Jeon Sun Och Yoon Jin Ho Paik Young A Kim Bong Kyung Shin Hyun-Jung Kim Hee Jeong Cha Ji Eun Kim Jooryung Huh Young-Hyeh Ko |
| author_facet | Yoon Kyung Jeon Sun Och Yoon Jin Ho Paik Young A Kim Bong Kyung Shin Hyun-Jung Kim Hee Jeong Cha Ji Eun Kim Jooryung Huh Young-Hyeh Ko |
| author_sort | Yoon Kyung Jeon |
| collection | DOAJ |
| description | Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized. |
| first_indexed | 2024-04-12T21:30:01Z |
| format | Article |
| id | doaj.art-4c49acbab7d740dfb6d25febeef70f9e |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-04-12T21:30:01Z |
| publishDate | 2017-05-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-4c49acbab7d740dfb6d25febeef70f9e2022-12-22T03:16:03ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452017-05-0151322424110.4132/jptm.2017.04.0916689Molecular Testing of Lymphoproliferative Disorders: Current Status and PerspectivesYoon Kyung JeonSun Och Yoon0Jin Ho Paik1Young A Kim2Bong Kyung Shin3Hyun-Jung Kim4Hee Jeong Cha5Ji Eun Kim6Jooryung Huh7Young-Hyeh Ko8 Department of Pathology, Yonsei University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Pathology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Korea University Guro Hospital, Korea University School of Medicine, Seoul, Korea Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea Department of Pathology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaMolecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.http://www.jpatholtm.org/upload/pdf/jptm-2017-04-09.pdfLymphoproliferative disordersMalignant lymphomaPathology, molecularMolecular diagnosticsClonality testGene translocationin situ hybridization, fluorescenceNext-generation sequencing |
| spellingShingle | Yoon Kyung Jeon Sun Och Yoon Jin Ho Paik Young A Kim Bong Kyung Shin Hyun-Jung Kim Hee Jeong Cha Ji Eun Kim Jooryung Huh Young-Hyeh Ko Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives Journal of Pathology and Translational Medicine Lymphoproliferative disorders Malignant lymphoma Pathology, molecular Molecular diagnostics Clonality test Gene translocation in situ hybridization, fluorescence Next-generation sequencing |
| title | Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives |
| title_full | Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives |
| title_fullStr | Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives |
| title_full_unstemmed | Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives |
| title_short | Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives |
| title_sort | molecular testing of lymphoproliferative disorders current status and perspectives |
| topic | Lymphoproliferative disorders Malignant lymphoma Pathology, molecular Molecular diagnostics Clonality test Gene translocation in situ hybridization, fluorescence Next-generation sequencing |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2017-04-09.pdf |
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