Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons

Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons

Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance seem to be quite complex, with suggestions in...

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Bibliographic Details
Main Authors:	Yusuke Ohashi, Fatma Zahra Sakhri, Hideshi Ikemoto, Takayuki Okumo, Naoki Adachi, Masataka Sunagawa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Pharmacology
Subjects:	morphine tolerance pain management traditional medicine kampo medicine spinal cord yokukansan
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.862539/full

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