A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A<sub>2</sub> on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A<sub>2</sub>α

A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A<sub>2</sub> on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A<sub>2</sub>α

Phospholipase A<sub>2</sub>s constitute a wide group of lipid-modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry-based lipidomic approaches to investigate the action of Asp-49 Ca<sup>2+</sup>-dependen...

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Bibliographic Details
Main Authors: Juan P. Rodríguez, Elbio Leiguez, Carlos Guijas, Bruno Lomonte, José M. Gutiérrez, Catarina Teixeira, María A. Balboa, Jesús Balsinde
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
phospholipase A<sub>2</sub>
lipidomics
mass spectrometry
lipid signaling
inflammation
monocytes/macrophages
Online Access:https://www.mdpi.com/2218-273X/10/6/891

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