Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy
AimsTemporal lobe epilepsy (TLE) is a common neurological disorder associated with the dysfunction of the default mode network (DMN). Metabolic connectivity measured by 18F-fluorodeoxyglucose Positron Emission Computed Tomography (18F-FDG PET) has been widely used to assess cumulative energy consump...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1011283/full |
| _version_ | 1797862095513976832 |
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| author | Xiaoyang Wang Xiaoyang Wang Dandan Lin Chunlei Zhao Chunlei Zhao Hui Li Liyuan Fu Liyuan Fu Zhifeng Huang Zhifeng Huang Shangwen Xu Shangwen Xu |
| author_facet | Xiaoyang Wang Xiaoyang Wang Dandan Lin Chunlei Zhao Chunlei Zhao Hui Li Liyuan Fu Liyuan Fu Zhifeng Huang Zhifeng Huang Shangwen Xu Shangwen Xu |
| author_sort | Xiaoyang Wang |
| collection | DOAJ |
| description | AimsTemporal lobe epilepsy (TLE) is a common neurological disorder associated with the dysfunction of the default mode network (DMN). Metabolic connectivity measured by 18F-fluorodeoxyglucose Positron Emission Computed Tomography (18F-FDG PET) has been widely used to assess cumulative energy consumption and provide valuable insights into the pathophysiology of TLE. However, the metabolic connectivity mechanism of DMN in TLE is far from fully elucidated. The present study investigated the metabolic connectivity mechanism of DMN in TLE using 18F-FDG PET.MethodParticipants included 40 TLE patients and 41 health controls (HC) who were age- and gender-matched. A weighted undirected metabolic network of each group was constructed based on 14 primary volumes of interest (VOIs) in the DMN, in which Pearson’s correlation coefficients between each pair-wise of the VOIs were calculated in an inter-subject manner. Graph theoretic analysis was then performed to analyze both global (global efficiency and the characteristic path length) and regional (nodal efficiency and degree centrality) network properties.ResultsMetabolic connectivity in DMN showed that regionally networks changed in the TLE group, including bilateral posterior cingulate gyrus, right inferior parietal gyrus, right angular gyrus, and left precuneus. Besides, significantly decreased (P < 0.05, FDR corrected) metabolic connections of DMN in the TLE group were revealed, containing bilateral hippocampus, bilateral posterior cingulate gyrus, bilateral angular gyrus, right medial of superior frontal gyrus, and left inferior parietal gyrus.ConclusionTaken together, the present study demonstrated the abnormal metabolic connectivity in DMN of TLE, which might provide further insights into the understanding the dysfunction mechanism and promote the treatment for TLE patients. |
| first_indexed | 2024-04-09T22:13:46Z |
| format | Article |
| id | doaj.art-4c4db3eec712464fb68d33d646267fea |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T22:13:46Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-4c4db3eec712464fb68d33d646267fea2023-03-23T04:54:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.10112831011283Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsyXiaoyang Wang0Xiaoyang Wang1Dandan Lin2Chunlei Zhao3Chunlei Zhao4Hui Li5Liyuan Fu6Liyuan Fu7Zhifeng Huang8Zhifeng Huang9Shangwen Xu10Shangwen Xu11Department of Medical Imaging, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, Fujian, ChinaDepartment of Clinical Medicine, Fujian Health College, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, ChinaDepartment of Medical Imaging, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, Fujian, ChinaAimsTemporal lobe epilepsy (TLE) is a common neurological disorder associated with the dysfunction of the default mode network (DMN). Metabolic connectivity measured by 18F-fluorodeoxyglucose Positron Emission Computed Tomography (18F-FDG PET) has been widely used to assess cumulative energy consumption and provide valuable insights into the pathophysiology of TLE. However, the metabolic connectivity mechanism of DMN in TLE is far from fully elucidated. The present study investigated the metabolic connectivity mechanism of DMN in TLE using 18F-FDG PET.MethodParticipants included 40 TLE patients and 41 health controls (HC) who were age- and gender-matched. A weighted undirected metabolic network of each group was constructed based on 14 primary volumes of interest (VOIs) in the DMN, in which Pearson’s correlation coefficients between each pair-wise of the VOIs were calculated in an inter-subject manner. Graph theoretic analysis was then performed to analyze both global (global efficiency and the characteristic path length) and regional (nodal efficiency and degree centrality) network properties.ResultsMetabolic connectivity in DMN showed that regionally networks changed in the TLE group, including bilateral posterior cingulate gyrus, right inferior parietal gyrus, right angular gyrus, and left precuneus. Besides, significantly decreased (P < 0.05, FDR corrected) metabolic connections of DMN in the TLE group were revealed, containing bilateral hippocampus, bilateral posterior cingulate gyrus, bilateral angular gyrus, right medial of superior frontal gyrus, and left inferior parietal gyrus.ConclusionTaken together, the present study demonstrated the abnormal metabolic connectivity in DMN of TLE, which might provide further insights into the understanding the dysfunction mechanism and promote the treatment for TLE patients.https://www.frontiersin.org/articles/10.3389/fnins.2023.1011283/fullTLE18F-FDG PETmetabolic connectivitydefault mode networkgraph theory |
| spellingShingle | Xiaoyang Wang Xiaoyang Wang Dandan Lin Chunlei Zhao Chunlei Zhao Hui Li Liyuan Fu Liyuan Fu Zhifeng Huang Zhifeng Huang Shangwen Xu Shangwen Xu Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy Frontiers in Neuroscience TLE 18F-FDG PET metabolic connectivity default mode network graph theory |
| title | Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy |
| title_full | Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy |
| title_fullStr | Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy |
| title_full_unstemmed | Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy |
| title_short | Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy |
| title_sort | abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy |
| topic | TLE 18F-FDG PET metabolic connectivity default mode network graph theory |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1011283/full |
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