Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain

Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain

Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental studies have intro...

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Main Authors: Ulises Gómez-Pinedo, Jordi A. Matías-Guiu, María Soledad Benito-Martín, Lidia Moreno-Jiménez, Inmaculada Sanclemente-Alamán, Belen Selma-Calvo, Sara Pérez-Suarez, Francisco Sancho-Bielsa, Alejandro Canales-Aguirre, Juan Carlos Mateos-Díaz, Mercedes A. Hernández-Sapiéns, Edwin E. Reza-Zaldívar, Doddy Denise Ojeda-Hernández, Lucía Vidorreta-Ballesteros, Paloma Montero-Escribano, Jorge Matías-Guiu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
multiple sclerosis
HOG cells
oligodendrocyte precursor cells
oligodendrocytes
intranasal administration
demyelination
Online Access:https://www.mdpi.com/1422-0067/22/19/10738

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