Molecular Mechanisms of Anticancer Activities of Puerarin
Bashir Ahmad,1,* Suliman Khan,2,3,* Yang Liu,2,3 Mengzhou Xue,2,3 Ghulam Nabi,4 Sunjeet Kumar,5 Mohammed Alshwmi,6 Abdul Wakeel Qarluq7 1Department of Pathology and Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of...
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| Format: | Article |
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Dove Medical Press
2020-01-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/molecular-mechanisms-of-anticancer-activities-of-puerarin-peer-reviewed-article-CMAR |
| _version_ | 1818877545648488448 |
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| author | Ahmad B Khan S Liu Y Xue M Nabi G Kumar S Alshwmi M Qarluq AW |
| author_facet | Ahmad B Khan S Liu Y Xue M Nabi G Kumar S Alshwmi M Qarluq AW |
| author_sort | Ahmad B |
| collection | DOAJ |
| description | Bashir Ahmad,1,* Suliman Khan,2,3,* Yang Liu,2,3 Mengzhou Xue,2,3 Ghulam Nabi,4 Sunjeet Kumar,5 Mohammed Alshwmi,6 Abdul Wakeel Qarluq7 1Department of Pathology and Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 2The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 3Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, People’s Republic of China; 4Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, People’s Republic of China; 5The Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People’s Republic of China; 6Department of Clinical Laboratory, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 7Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mengzhou Xue; Ghulam Nabi Email xuemengzhou@zzu.edu.cn; ghulamnabiqau@gmail.comAbstract: Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment.Keywords: medicinal plants, natural products, Puerarin, Pueraria lobata, Pueraria thomsonii, Pueraria tuberosa |
| first_indexed | 2024-12-19T13:59:59Z |
| format | Article |
| id | doaj.art-4c4e8fcc5527423589d612bce913d3c3 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T13:59:59Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-4c4e8fcc5527423589d612bce913d3c32022-12-21T20:18:29ZengDove Medical PressCancer Management and Research1179-13222020-01-01Volume 12799050977Molecular Mechanisms of Anticancer Activities of PuerarinAhmad BKhan SLiu YXue MNabi GKumar SAlshwmi MQarluq AWBashir Ahmad,1,* Suliman Khan,2,3,* Yang Liu,2,3 Mengzhou Xue,2,3 Ghulam Nabi,4 Sunjeet Kumar,5 Mohammed Alshwmi,6 Abdul Wakeel Qarluq7 1Department of Pathology and Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 2The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 3Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, People’s Republic of China; 4Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, People’s Republic of China; 5The Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People’s Republic of China; 6Department of Clinical Laboratory, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 7Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mengzhou Xue; Ghulam Nabi Email xuemengzhou@zzu.edu.cn; ghulamnabiqau@gmail.comAbstract: Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment.Keywords: medicinal plants, natural products, Puerarin, Pueraria lobata, Pueraria thomsonii, Pueraria tuberosahttps://www.dovepress.com/molecular-mechanisms-of-anticancer-activities-of-puerarin-peer-reviewed-article-CMARmedicinal plantsnatural productspuerarinpueraria lobatapueraria thomsoniipueraria tuberosa |
| spellingShingle | Ahmad B Khan S Liu Y Xue M Nabi G Kumar S Alshwmi M Qarluq AW Molecular Mechanisms of Anticancer Activities of Puerarin Cancer Management and Research medicinal plants natural products puerarin pueraria lobata pueraria thomsonii pueraria tuberosa |
| title | Molecular Mechanisms of Anticancer Activities of Puerarin |
| title_full | Molecular Mechanisms of Anticancer Activities of Puerarin |
| title_fullStr | Molecular Mechanisms of Anticancer Activities of Puerarin |
| title_full_unstemmed | Molecular Mechanisms of Anticancer Activities of Puerarin |
| title_short | Molecular Mechanisms of Anticancer Activities of Puerarin |
| title_sort | molecular mechanisms of anticancer activities of puerarin |
| topic | medicinal plants natural products puerarin pueraria lobata pueraria thomsonii pueraria tuberosa |
| url | https://www.dovepress.com/molecular-mechanisms-of-anticancer-activities-of-puerarin-peer-reviewed-article-CMAR |
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