Imaging body composition in obesity and weight loss: challenges and opportunities
Heidi J Silver1, E Brian Welch2, Malcolm J Avison2, Kevin D Niswender1,31Department of Medicine, 2Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, USA; 3Tennessee Valley Healthcare System, Nashville, TN, USAAbstract: Obesity is a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2010-09-01
|
| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/imaging-body-composition-in-obesity-and-weight-loss-challenges-and-opp-peer-reviewed-article-DMSO |
| _version_ | 1811174068065402880 |
|---|---|
| author | Silver HJ Welch B Avison MJ Niswender KD |
| author_facet | Silver HJ Welch B Avison MJ Niswender KD |
| author_sort | Silver HJ |
| collection | DOAJ |
| description | Heidi J Silver1, E Brian Welch2, Malcolm J Avison2, Kevin D Niswender1,31Department of Medicine, 2Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, USA; 3Tennessee Valley Healthcare System, Nashville, TN, USAAbstract: Obesity is a threat to public health worldwide primarily due to the comorbidities related to visceral adiposity, inflammation, and insulin resistance that increase risk for type 2 diabetes and cardiovascular disease. The translational research portfolio that originally described these risk factors was significantly enhanced by imaging techniques, such as dual-energy X-ray absorptiometry (DEXA), computed tomography (CT), and magnetic resonance imaging (MRI). In this article, we briefly review the important contributions of these techniques to understand the role of body composition in the pathogenesis of obesity-related complications. Notably, these imaging techniques have contributed greatly to recent findings identifying gender and racial differences in body composition and patterns of body composition change during weight loss. Although these techniques have the ability to generate good-quality body composition data, each possesses limitations. For example, DEXA is unable to differentiate type of fat, CT has better resolution but provides greater ionizing radiation exposure, and MRI tends to require longer imaging times and specialized equipment for acquisition and analysis. With the serious need for efficacious and cost-effective therapies to appropriately identify and treat at-risk obese individuals, there is greater need for translational tools that can further elucidate the interplay between body composition and the metabolic aberrations associated with obesity. In conclusion, we will offer our perspective on the evolution toward an ideal imaging method for body composition assessment in obesity and weight loss, and the challenges remaining to achieve this goal.Keywords: obesity, imaging, body composition, visceral fat |
| first_indexed | 2024-04-10T17:58:13Z |
| format | Article |
| id | doaj.art-4c4f8adb169c4295a90190cbb4884850 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:58:13Z |
| publishDate | 2010-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-4c4f8adb169c4295a90190cbb48848502023-02-02T17:09:59ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072010-09-01Volume 33373475384Imaging body composition in obesity and weight loss: challenges and opportunitiesSilver HJWelch BAvison MJNiswender KDHeidi J Silver1, E Brian Welch2, Malcolm J Avison2, Kevin D Niswender1,31Department of Medicine, 2Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, USA; 3Tennessee Valley Healthcare System, Nashville, TN, USAAbstract: Obesity is a threat to public health worldwide primarily due to the comorbidities related to visceral adiposity, inflammation, and insulin resistance that increase risk for type 2 diabetes and cardiovascular disease. The translational research portfolio that originally described these risk factors was significantly enhanced by imaging techniques, such as dual-energy X-ray absorptiometry (DEXA), computed tomography (CT), and magnetic resonance imaging (MRI). In this article, we briefly review the important contributions of these techniques to understand the role of body composition in the pathogenesis of obesity-related complications. Notably, these imaging techniques have contributed greatly to recent findings identifying gender and racial differences in body composition and patterns of body composition change during weight loss. Although these techniques have the ability to generate good-quality body composition data, each possesses limitations. For example, DEXA is unable to differentiate type of fat, CT has better resolution but provides greater ionizing radiation exposure, and MRI tends to require longer imaging times and specialized equipment for acquisition and analysis. With the serious need for efficacious and cost-effective therapies to appropriately identify and treat at-risk obese individuals, there is greater need for translational tools that can further elucidate the interplay between body composition and the metabolic aberrations associated with obesity. In conclusion, we will offer our perspective on the evolution toward an ideal imaging method for body composition assessment in obesity and weight loss, and the challenges remaining to achieve this goal.Keywords: obesity, imaging, body composition, visceral fathttps://www.dovepress.com/imaging-body-composition-in-obesity-and-weight-loss-challenges-and-opp-peer-reviewed-article-DMSOimagingbody compositionobesitymagnetic resonance imagingfat-water imaging |
| spellingShingle | Silver HJ Welch B Avison MJ Niswender KD Imaging body composition in obesity and weight loss: challenges and opportunities Diabetes, Metabolic Syndrome and Obesity imaging body composition obesity magnetic resonance imaging fat-water imaging |
| title | Imaging body composition in obesity and weight loss: challenges and opportunities |
| title_full | Imaging body composition in obesity and weight loss: challenges and opportunities |
| title_fullStr | Imaging body composition in obesity and weight loss: challenges and opportunities |
| title_full_unstemmed | Imaging body composition in obesity and weight loss: challenges and opportunities |
| title_short | Imaging body composition in obesity and weight loss: challenges and opportunities |
| title_sort | imaging body composition in obesity and weight loss challenges and opportunities |
| topic | imaging body composition obesity magnetic resonance imaging fat-water imaging |
| url | https://www.dovepress.com/imaging-body-composition-in-obesity-and-weight-loss-challenges-and-opp-peer-reviewed-article-DMSO |
| work_keys_str_mv | AT silverhj imagingbodycompositioninobesityandweightlosschallengesandopportunities AT welchb imagingbodycompositioninobesityandweightlosschallengesandopportunities AT avisonmj imagingbodycompositioninobesityandweightlosschallengesandopportunities AT niswenderkd imagingbodycompositioninobesityandweightlosschallengesandopportunities |