Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study
(1) Background: Vitamin D plays an important role in many types of cancer. It was the aim of this study to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients, and the association with prognostic and lifestyle factors. (2) Methods: 110 non-metastatic breast c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/6/1450 |
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| author | Cosima Zemlin Laura Altmayer Caroline Stuhlert Julia Theresa Schleicher Carolin Wörmann Marina Lang Laura-Sophie Scherer Ida Clara Thul Lisanne Sophie Spenner Jana Alisa Simon Alina Wind Elisabeth Kaiser Regine Weber Sybelle Goedicke-Fritz Gudrun Wagenpfeil Michael Zemlin Erich-Franz Solomayer Jörg Reichrath Carolin Müller |
| author_facet | Cosima Zemlin Laura Altmayer Caroline Stuhlert Julia Theresa Schleicher Carolin Wörmann Marina Lang Laura-Sophie Scherer Ida Clara Thul Lisanne Sophie Spenner Jana Alisa Simon Alina Wind Elisabeth Kaiser Regine Weber Sybelle Goedicke-Fritz Gudrun Wagenpfeil Michael Zemlin Erich-Franz Solomayer Jörg Reichrath Carolin Müller |
| author_sort | Cosima Zemlin |
| collection | DOAJ |
| description | (1) Background: Vitamin D plays an important role in many types of cancer. It was the aim of this study to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients, and the association with prognostic and lifestyle factors. (2) Methods: 110 non-metastatic breast cancer patients were included in the prospective observational “BEGYN” study at Saarland University Medical Center between September 2019 and January 2021. At the initiation visit, serum 25(OH)D levels were measured. Clinicopathological data on prognosis, nutrition, and lifestyle were extracted from data files and obtained using a questionnaire. (3) Results: Median serum 25(OH)D in breast cancer patients was 24 ng/mL (range 5–65 ng/mL), with 64.8% of patients being vitamin D deficient. 25(OH)D was higher among patients that reported the use of vitamin D supplements (43 ng/mL versus 22 ng/mL; <i>p</i> < 0.001), and in summer compared to other seasons (<i>p</i> = 0.03). Patients with moderate vitamin D deficiency were less likely to have triple negative breast cancer (<i>p</i> = 0.047). (4) Conclusions: Routinely measured vitamin D deficiency is common in breast cancer patients and needs to be detected and treated. However, our results do not support the hypothesis that vitamin D deficiency may be a main prognostic factor for breast cancer. |
| first_indexed | 2024-03-11T06:04:04Z |
| format | Article |
| id | doaj.art-4c4fcf1858c144f8ac3d4c6651beec6e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T06:04:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4c4fcf1858c144f8ac3d4c6651beec6e2023-11-17T13:05:57ZengMDPI AGNutrients2072-66432023-03-01156145010.3390/nu15061450Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot StudyCosima Zemlin0Laura Altmayer1Caroline Stuhlert2Julia Theresa Schleicher3Carolin Wörmann4Marina Lang5Laura-Sophie Scherer6Ida Clara Thul7Lisanne Sophie Spenner8Jana Alisa Simon9Alina Wind10Elisabeth Kaiser11Regine Weber12Sybelle Goedicke-Fritz13Gudrun Wagenpfeil14Michael Zemlin15Erich-Franz Solomayer16Jörg Reichrath17Carolin Müller18Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, GermanyInstitute for Medical Biometry, Epidemiology and Medical Informatics (IMBEI), Saarland University, Campus Homburg, 66421 Homburg, GermanyDepartment of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Dermatology, Venereology and Allergology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany(1) Background: Vitamin D plays an important role in many types of cancer. It was the aim of this study to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients, and the association with prognostic and lifestyle factors. (2) Methods: 110 non-metastatic breast cancer patients were included in the prospective observational “BEGYN” study at Saarland University Medical Center between September 2019 and January 2021. At the initiation visit, serum 25(OH)D levels were measured. Clinicopathological data on prognosis, nutrition, and lifestyle were extracted from data files and obtained using a questionnaire. (3) Results: Median serum 25(OH)D in breast cancer patients was 24 ng/mL (range 5–65 ng/mL), with 64.8% of patients being vitamin D deficient. 25(OH)D was higher among patients that reported the use of vitamin D supplements (43 ng/mL versus 22 ng/mL; <i>p</i> < 0.001), and in summer compared to other seasons (<i>p</i> = 0.03). Patients with moderate vitamin D deficiency were less likely to have triple negative breast cancer (<i>p</i> = 0.047). (4) Conclusions: Routinely measured vitamin D deficiency is common in breast cancer patients and needs to be detected and treated. However, our results do not support the hypothesis that vitamin D deficiency may be a main prognostic factor for breast cancer.https://www.mdpi.com/2072-6643/15/6/1450vitamin Dprognostic factorsbreast cancernutrition |
| spellingShingle | Cosima Zemlin Laura Altmayer Caroline Stuhlert Julia Theresa Schleicher Carolin Wörmann Marina Lang Laura-Sophie Scherer Ida Clara Thul Lisanne Sophie Spenner Jana Alisa Simon Alina Wind Elisabeth Kaiser Regine Weber Sybelle Goedicke-Fritz Gudrun Wagenpfeil Michael Zemlin Erich-Franz Solomayer Jörg Reichrath Carolin Müller Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study Nutrients vitamin D prognostic factors breast cancer nutrition |
| title | Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study |
| title_full | Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study |
| title_fullStr | Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study |
| title_full_unstemmed | Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study |
| title_short | Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study |
| title_sort | prevalence and relevance of vitamin d deficiency in newly diagnosed breast cancer patients a pilot study |
| topic | vitamin D prognostic factors breast cancer nutrition |
| url | https://www.mdpi.com/2072-6643/15/6/1450 |
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