Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?
The metabolic state of pregnant women and their unborn children changes throughout pregnancy and adapts to the specific needs of each gestational week. These adaptions are accomplished by the actions of enzymes, which regulate the occurrence of their endogenous substrates and products in all three c...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6851 |
| _version_ | 1797486291803176960 |
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| author | Natascha Berger Hanna Allerkamp Christian Wadsack |
| author_facet | Natascha Berger Hanna Allerkamp Christian Wadsack |
| author_sort | Natascha Berger |
| collection | DOAJ |
| description | The metabolic state of pregnant women and their unborn children changes throughout pregnancy and adapts to the specific needs of each gestational week. These adaptions are accomplished by the actions of enzymes, which regulate the occurrence of their endogenous substrates and products in all three compartments: mother, placenta and the unborn. These enzymes determine bioactive lipid signaling, supply, and storage through the generation or degradation of lipids and fatty acids, respectively. This review focuses on the role of lipid-metabolizing serine hydrolases during normal pregnancy and in pregnancy-associated pathologies, such as preeclampsia, gestational diabetes mellitus, or preterm birth. The biochemical properties of each class of lipid hydrolases are presented, with special emphasis on their role in placental function or dysfunction. While, during a normal pregnancy, an appropriate tonus of bioactive lipids prevails, dysregulation and aberrant signaling occur in diseased states. A better understanding of the dynamics of serine hydrolases across gestation and their involvement in placental lipid homeostasis under physiological and pathophysiological conditions will help to identify new targets for placental function in the future. |
| first_indexed | 2024-03-09T23:32:02Z |
| format | Article |
| id | doaj.art-4c500c64cb0a42648c3a33f86e48f5ee |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:32:02Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4c500c64cb0a42648c3a33f86e48f5ee2023-11-23T17:07:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312685110.3390/ijms23126851Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?Natascha Berger0Hanna Allerkamp1Christian Wadsack2Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, AustriaThe metabolic state of pregnant women and their unborn children changes throughout pregnancy and adapts to the specific needs of each gestational week. These adaptions are accomplished by the actions of enzymes, which regulate the occurrence of their endogenous substrates and products in all three compartments: mother, placenta and the unborn. These enzymes determine bioactive lipid signaling, supply, and storage through the generation or degradation of lipids and fatty acids, respectively. This review focuses on the role of lipid-metabolizing serine hydrolases during normal pregnancy and in pregnancy-associated pathologies, such as preeclampsia, gestational diabetes mellitus, or preterm birth. The biochemical properties of each class of lipid hydrolases are presented, with special emphasis on their role in placental function or dysfunction. While, during a normal pregnancy, an appropriate tonus of bioactive lipids prevails, dysregulation and aberrant signaling occur in diseased states. A better understanding of the dynamics of serine hydrolases across gestation and their involvement in placental lipid homeostasis under physiological and pathophysiological conditions will help to identify new targets for placental function in the future.https://www.mdpi.com/1422-0067/23/12/6851serine hydrolaseslipasesplacentaplacental metabolismpregnancy disorders |
| spellingShingle | Natascha Berger Hanna Allerkamp Christian Wadsack Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function? International Journal of Molecular Sciences serine hydrolases lipases placenta placental metabolism pregnancy disorders |
| title | Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function? |
| title_full | Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function? |
| title_fullStr | Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function? |
| title_full_unstemmed | Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function? |
| title_short | Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function? |
| title_sort | serine hydrolases in lipid homeostasis of the placenta targets for placental function |
| topic | serine hydrolases lipases placenta placental metabolism pregnancy disorders |
| url | https://www.mdpi.com/1422-0067/23/12/6851 |
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