Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island
The members of Cystus genus are perenial shrubs with a well-established use in traditional medicine. Among these, C. creticus is the most popular, herbal preparations obtained from its aerial parts being recognized as antimicrobial, antitumor and anti-inflammatory agents. The present study aimed to...
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Frontiers Media S.A.
2022-05-01
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| 丛编: | Frontiers in Nutrition |
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| 在线阅读: | https://www.frontiersin.org/articles/10.3389/fnut.2022.881210/full |
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| author | Andrei Mocan Andrei Mocan Ângela Fernandes Ricardo C. Calhelha Laura Gavrilaş Isabel C. F. R. Ferreira Marija Ivanov Marina Sokovic Lillian Barros Mihai Babotă |
| author_facet | Andrei Mocan Andrei Mocan Ângela Fernandes Ricardo C. Calhelha Laura Gavrilaş Isabel C. F. R. Ferreira Marija Ivanov Marina Sokovic Lillian Barros Mihai Babotă |
| author_sort | Andrei Mocan |
| collection | DOAJ |
| description | The members of Cystus genus are perenial shrubs with a well-established use in traditional medicine. Among these, C. creticus is the most popular, herbal preparations obtained from its aerial parts being recognized as antimicrobial, antitumor and anti-inflammatory agents. The present study aimed to evaluate phytochemical profile and bioactive potential of aqueous and hydroethanolic extracts of C. creticus aerial parts harvested from two different areas of Rhodes island. LC-DAD-ESI/MSn analysis revealed the presence of myricetin and quercetin glycosides as main compounds, especially in aqueous extracts, being probably responsible for their enhanced antioxidant and antimicrobial potential. On the other side, hydroethanolic preparations exerted a strong anti-inflammatory and anti-biofilm activity. Our findings suggest that the use of solvents with intermediate polarity can assure the best recovery of bioactive compounds from C. creticus, increasing the extraction yield for other non-phenolic compounds which can enhance therapeutic potential of the extract through a synergistic action. |
| first_indexed | 2024-04-13T18:50:24Z |
| format | Article |
| id | doaj.art-4c507eeae8f84ada8c4fad9d7c9ca82f |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T18:50:24Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-4c507eeae8f84ada8c4fad9d7c9ca82f2022-12-22T02:34:27ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.881210881210Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes IslandAndrei Mocan0Andrei Mocan1Ângela Fernandes2Ricardo C. Calhelha3Laura Gavrilaş4Isabel C. F. R. Ferreira5Marija Ivanov6Marina Sokovic7Lillian Barros8Mihai Babotă9Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaLaboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, RomaniaCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, PortugalCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, PortugalFaculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, PortugalInstitute for Biological Research “Siniša Stanković”– National Institute of Republic of Serbia, University of Belgrade, Belgrade, SerbiaInstitute for Biological Research “Siniša Stanković”– National Institute of Republic of Serbia, University of Belgrade, Belgrade, SerbiaCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, PortugalFaculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaThe members of Cystus genus are perenial shrubs with a well-established use in traditional medicine. Among these, C. creticus is the most popular, herbal preparations obtained from its aerial parts being recognized as antimicrobial, antitumor and anti-inflammatory agents. The present study aimed to evaluate phytochemical profile and bioactive potential of aqueous and hydroethanolic extracts of C. creticus aerial parts harvested from two different areas of Rhodes island. LC-DAD-ESI/MSn analysis revealed the presence of myricetin and quercetin glycosides as main compounds, especially in aqueous extracts, being probably responsible for their enhanced antioxidant and antimicrobial potential. On the other side, hydroethanolic preparations exerted a strong anti-inflammatory and anti-biofilm activity. Our findings suggest that the use of solvents with intermediate polarity can assure the best recovery of bioactive compounds from C. creticus, increasing the extraction yield for other non-phenolic compounds which can enhance therapeutic potential of the extract through a synergistic action.https://www.frontiersin.org/articles/10.3389/fnut.2022.881210/fullbioactive compoundsnatural antioxidantantimicrobial compoundsCystus creticusherbal preparations |
| spellingShingle | Andrei Mocan Andrei Mocan Ângela Fernandes Ricardo C. Calhelha Laura Gavrilaş Isabel C. F. R. Ferreira Marija Ivanov Marina Sokovic Lillian Barros Mihai Babotă Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island Frontiers in Nutrition bioactive compounds natural antioxidant antimicrobial compounds Cystus creticus herbal preparations |
| title | Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island |
| title_full | Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island |
| title_fullStr | Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island |
| title_full_unstemmed | Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island |
| title_short | Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island |
| title_sort | bioactive compounds and functional properties of herbal preparations of cystus creticus l collected from rhodes island |
| topic | bioactive compounds natural antioxidant antimicrobial compounds Cystus creticus herbal preparations |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.881210/full |
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