On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease
Ischemic brain injury and Alzheimer’s disease (AD) both lead to cell death in the central nervous system (CNS) and thus negatively affect particularly the elderly population. Due to the lack of a definitive cure for brain ischemia and AD, it is advisable to carefully study, compare, and contrast the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/18/9689 |
| _version_ | 1797518956772196352 |
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| author | Jan Kriska Zuzana Hermanova Tomas Knotek Jana Tureckova Miroslava Anderova |
| author_facet | Jan Kriska Zuzana Hermanova Tomas Knotek Jana Tureckova Miroslava Anderova |
| author_sort | Jan Kriska |
| collection | DOAJ |
| description | Ischemic brain injury and Alzheimer’s disease (AD) both lead to cell death in the central nervous system (CNS) and thus negatively affect particularly the elderly population. Due to the lack of a definitive cure for brain ischemia and AD, it is advisable to carefully study, compare, and contrast the mechanisms that trigger, and are involved in, both neuropathologies. A deeper understanding of these mechanisms may help ameliorate, or even prevent, the destructive effects of neurodegenerative disorders. In this review, we deal with ischemic damage and AD, with the main emphasis on the common properties of these CNS disorders. Importantly, we discuss the Wnt signaling pathway as a significant factor in the cell fate determination and cell survival in the diseased adult CNS. Finally, we summarize the interesting findings that may improve or complement the current sparse and insufficient treatments for brain ischemia and AD, and we delineate prospective directions in regenerative medicine. |
| first_indexed | 2024-03-10T07:36:38Z |
| format | Article |
| id | doaj.art-4c517f3b2a354c4bb1eafa1681828acf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:36:38Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4c517f3b2a354c4bb1eafa1681828acf2023-11-22T13:25:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-012218968910.3390/ijms22189689On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s DiseaseJan Kriska0Zuzana Hermanova1Tomas Knotek2Jana Tureckova3Miroslava Anderova4Institute of Experimental Medicine, Czech Academy of Sciences, 142 20 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, 142 20 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, 142 20 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, 142 20 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, 142 20 Prague, Czech RepublicIschemic brain injury and Alzheimer’s disease (AD) both lead to cell death in the central nervous system (CNS) and thus negatively affect particularly the elderly population. Due to the lack of a definitive cure for brain ischemia and AD, it is advisable to carefully study, compare, and contrast the mechanisms that trigger, and are involved in, both neuropathologies. A deeper understanding of these mechanisms may help ameliorate, or even prevent, the destructive effects of neurodegenerative disorders. In this review, we deal with ischemic damage and AD, with the main emphasis on the common properties of these CNS disorders. Importantly, we discuss the Wnt signaling pathway as a significant factor in the cell fate determination and cell survival in the diseased adult CNS. Finally, we summarize the interesting findings that may improve or complement the current sparse and insufficient treatments for brain ischemia and AD, and we delineate prospective directions in regenerative medicine.https://www.mdpi.com/1422-0067/22/18/9689central nervous systemischemic brain injurystrokeAlzheimer’s diseasedementianeurodegeneration |
| spellingShingle | Jan Kriska Zuzana Hermanova Tomas Knotek Jana Tureckova Miroslava Anderova On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease International Journal of Molecular Sciences central nervous system ischemic brain injury stroke Alzheimer’s disease dementia neurodegeneration |
| title | On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease |
| title_full | On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease |
| title_fullStr | On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease |
| title_full_unstemmed | On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease |
| title_short | On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease |
| title_sort | on the common journey of neural cells through ischemic brain injury and alzheimer s disease |
| topic | central nervous system ischemic brain injury stroke Alzheimer’s disease dementia neurodegeneration |
| url | https://www.mdpi.com/1422-0067/22/18/9689 |
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