A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

Abstract Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is a direct precursor for the synthesis of drugs such as citicoline. In this study, we established an in vitro six-enzyme cascade system to gener...

Descripció completa

Dades bibliogràfiques
Autors principals: Zonglin Li, Yahui Zhong, Zhoulei Qing, Zhimin Li
Format: Article
Idioma:English
Publicat: SpringerOpen 2024-01-01
Col·lecció:Bioresources and Bioprocessing
Matèries:
CTP
In vitro
Multi-enzymatic cascade
Circuitous route
Directed evolution
CTP synthetase
Accés en línia:https://doi.org/10.1186/s40643-023-00724-6

Internet

https://doi.org/10.1186/s40643-023-00724-6

Ítems similars