Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis
Abstract Background The study aimed to investigate novel biomarkers from the C1q TNF superfamily and evaluate their role in autoimmune inflammatory rheumatic diseases with the goal of identifying an effective biomarker to measure clinical disease activity and assess treatment efficacy. Methods Sixty...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Rheumatology |
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| Online Access: | https://doi.org/10.1186/s41927-023-00356-5 |
| _version_ | 1797451116218155008 |
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| author | İ.Merve B. Uçar Gökhan Sargin Ayça Tuzcu Songül Çildağ Taşkın Şentürk |
| author_facet | İ.Merve B. Uçar Gökhan Sargin Ayça Tuzcu Songül Çildağ Taşkın Şentürk |
| author_sort | İ.Merve B. Uçar |
| collection | DOAJ |
| description | Abstract Background The study aimed to investigate novel biomarkers from the C1q TNF superfamily and evaluate their role in autoimmune inflammatory rheumatic diseases with the goal of identifying an effective biomarker to measure clinical disease activity and assess treatment efficacy. Methods Sixty-one Axial spondyloarthritis (AxSpa) patients and 30 healthy controls were enrolled in the study. The serum biomarkers subfatin, CTHRC1, CTRP3, CTRP6, IL-6, IL-17, and TNF-α and the disease indices BASDAI, BASFI, MASES, and ASDAS–ESR/CRP were evaluated and compared. The patients were then classified, and their serum biomarkers were assessed according to their ASDAS scores and their treatment regimens. Results Among the studied biomarkers, none showed a significant difference between the patients and the healthy controls. Although the difference was not statistically significant, the median values of serum subfatin, CTHRC1, CTRP3, CTRP6, IL-6, IL-17, and TNF-α were all found to be lower in the AxSpa patients than in the healthy controls. Furthermore, once the patients were classified regarding their disease activity, no correlation between the study biomarkers and levels of clinical disease indices was observed. Finally, biological treatments were found to affect the serum concentration of these biomarkers regardless of the level of disease activity. Conclusion Novel adipokines and known modulators of inflammation, circulating subfatin, CTHRC1, CTRP3, CTRP6, IL-6, IL-17, and TNF-α levels may play a role in assessing treatment efficacy, especially in those treated with TNF-inhibitors. However, we failed to demonstrate a correlation between clinical disease activity and serum biomarker levels. |
| first_indexed | 2024-03-09T14:49:13Z |
| format | Article |
| id | doaj.art-4c558c37415941d9b809b3337eb461cb |
| institution | Directory Open Access Journal |
| issn | 2520-1026 |
| language | English |
| last_indexed | 2024-03-09T14:49:13Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Rheumatology |
| spelling | doaj.art-4c558c37415941d9b809b3337eb461cb2023-11-26T14:32:27ZengBMCBMC Rheumatology2520-10262023-09-01711510.1186/s41927-023-00356-5Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritisİ.Merve B. Uçar0Gökhan Sargin1Ayça Tuzcu2Songül Çildağ3Taşkın Şentürk4Department of Internal Medicine, Usak Research and Training HospitalDepartment of Internal Medicine, Aydin Adnan Menderes UniversityFaculty of Medicine, Department of Biochemistry, Aydin Adnan Menderes UniversityDepartment of Internal Medicine, Aydin Adnan Menderes UniversityDepartment of Internal Medicine, Aydin Adnan Menderes UniversityAbstract Background The study aimed to investigate novel biomarkers from the C1q TNF superfamily and evaluate their role in autoimmune inflammatory rheumatic diseases with the goal of identifying an effective biomarker to measure clinical disease activity and assess treatment efficacy. Methods Sixty-one Axial spondyloarthritis (AxSpa) patients and 30 healthy controls were enrolled in the study. The serum biomarkers subfatin, CTHRC1, CTRP3, CTRP6, IL-6, IL-17, and TNF-α and the disease indices BASDAI, BASFI, MASES, and ASDAS–ESR/CRP were evaluated and compared. The patients were then classified, and their serum biomarkers were assessed according to their ASDAS scores and their treatment regimens. Results Among the studied biomarkers, none showed a significant difference between the patients and the healthy controls. Although the difference was not statistically significant, the median values of serum subfatin, CTHRC1, CTRP3, CTRP6, IL-6, IL-17, and TNF-α were all found to be lower in the AxSpa patients than in the healthy controls. Furthermore, once the patients were classified regarding their disease activity, no correlation between the study biomarkers and levels of clinical disease indices was observed. Finally, biological treatments were found to affect the serum concentration of these biomarkers regardless of the level of disease activity. Conclusion Novel adipokines and known modulators of inflammation, circulating subfatin, CTHRC1, CTRP3, CTRP6, IL-6, IL-17, and TNF-α levels may play a role in assessing treatment efficacy, especially in those treated with TNF-inhibitors. However, we failed to demonstrate a correlation between clinical disease activity and serum biomarker levels.https://doi.org/10.1186/s41927-023-00356-5SpondyloarthritisDisease indicesSubfatinMetrnlTNF-αCTRP3 |
| spellingShingle | İ.Merve B. Uçar Gökhan Sargin Ayça Tuzcu Songül Çildağ Taşkın Şentürk Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis BMC Rheumatology Spondyloarthritis Disease indices Subfatin Metrnl TNF-α CTRP3 |
| title | Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis |
| title_full | Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis |
| title_fullStr | Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis |
| title_full_unstemmed | Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis |
| title_short | Correlation of serum subfatin, cthrc1, ctrp3, ctrp6 levels with disease indices in patients with axial spondyloarthritis |
| title_sort | correlation of serum subfatin cthrc1 ctrp3 ctrp6 levels with disease indices in patients with axial spondyloarthritis |
| topic | Spondyloarthritis Disease indices Subfatin Metrnl TNF-α CTRP3 |
| url | https://doi.org/10.1186/s41927-023-00356-5 |
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