Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children
Objective: To assess whether the -675 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is associated with obesity and insulin resistance in Mexican children. Methods: A cross-sectional study was performed in 174 children, 89 with normal-weight and 85 with obesity, aged from 6 to 13 y...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2013-09-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553613000955 |
| _version_ | 1828159874020671488 |
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| author | Ulises de la Cruz-Mosso José Francisco Muñoz-Valle Aralia Berenice Salgado-Bernabé Natividad Castro-Alarcón Lorenzo Salgado-Goytia José Sánchez-Corona Silvia Esperanza Flores-Martínez Isela Parra-Rojas |
| author_facet | Ulises de la Cruz-Mosso José Francisco Muñoz-Valle Aralia Berenice Salgado-Bernabé Natividad Castro-Alarcón Lorenzo Salgado-Goytia José Sánchez-Corona Silvia Esperanza Flores-Martínez Isela Parra-Rojas |
| author_sort | Ulises de la Cruz-Mosso |
| collection | DOAJ |
| description | Objective: To assess whether the -675 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is associated with obesity and insulin resistance in Mexican children.
Methods: A cross-sectional study was performed in 174 children, 89 with normal-weight and 85 with obesity, aged from 6 to 13 years. All children were from state of Guerrero, and recruited from three primary schools in the city of Chilpancingo, Mexico. Insulin levels were determined by immunoenzymatic assay. The homeostasis model assessment was used to determine insulin resistance. The -675 4G/5G polymorphism in PAI-1 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism.
Results: The prevalence of insulin resistance in the obese group was higher (49.41%) than in the normal-weight group (16.85%). The 4G/5G PAI-1 polymorphism was found in Hardy Weinberg equilibrium. The 4G/5G genotype contributed to a significant increase in waist-hip ratio (b = 0.02, p = 0.006), waist circumference (b = 4.42, p = 0.009), and subscapular skinfold thickness (b = 1.79, p = 0.04); however, it was not related with insulin resistance.
Conclusion: The -675 4G/5G genotype of PAI-1 gene was associated with increase of body adiposity in Mexican children. |
| first_indexed | 2024-04-12T00:09:22Z |
| format | Article |
| id | doaj.art-4c55b882df5749858a816c3f88890b88 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T00:09:22Z |
| publishDate | 2013-09-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-4c55b882df5749858a816c3f88890b882022-12-22T03:56:01ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362013-09-0189549249810.1016/j.jpedp.2013.01.005Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican childrenUlises de la Cruz-Mosso0José Francisco Muñoz-Valle1Aralia Berenice Salgado-Bernabé2Natividad Castro-Alarcón3Lorenzo Salgado-Goytia4José Sánchez-Corona5Silvia Esperanza Flores-Martínez6Isela Parra-Rojas7BSc, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, MéxicoDoutor, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MéxicoBSc, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, MéxicoDoutora, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, MéxicoDoutora, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, MéxicoDoutor, División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, MéxicoDoutor, División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, MéxicoDoutora, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, MéxicoObjective: To assess whether the -675 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is associated with obesity and insulin resistance in Mexican children. Methods: A cross-sectional study was performed in 174 children, 89 with normal-weight and 85 with obesity, aged from 6 to 13 years. All children were from state of Guerrero, and recruited from three primary schools in the city of Chilpancingo, Mexico. Insulin levels were determined by immunoenzymatic assay. The homeostasis model assessment was used to determine insulin resistance. The -675 4G/5G polymorphism in PAI-1 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism. Results: The prevalence of insulin resistance in the obese group was higher (49.41%) than in the normal-weight group (16.85%). The 4G/5G PAI-1 polymorphism was found in Hardy Weinberg equilibrium. The 4G/5G genotype contributed to a significant increase in waist-hip ratio (b = 0.02, p = 0.006), waist circumference (b = 4.42, p = 0.009), and subscapular skinfold thickness (b = 1.79, p = 0.04); however, it was not related with insulin resistance. Conclusion: The -675 4G/5G genotype of PAI-1 gene was associated with increase of body adiposity in Mexican children.http://www.sciencedirect.com/science/article/pii/S2255553613000955PAI-1 genePolymorphismsBody adiposityInsulin resistance |
| spellingShingle | Ulises de la Cruz-Mosso José Francisco Muñoz-Valle Aralia Berenice Salgado-Bernabé Natividad Castro-Alarcón Lorenzo Salgado-Goytia José Sánchez-Corona Silvia Esperanza Flores-Martínez Isela Parra-Rojas Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children Jornal de Pediatria (Versão em Português) PAI-1 gene Polymorphisms Body adiposity Insulin resistance |
| title | Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children |
| title_full | Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children |
| title_fullStr | Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children |
| title_full_unstemmed | Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children |
| title_short | Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children |
| title_sort | body adiposity but not insulin resistance is associated with 675 4g 5g polymorphism in the pai 1 gene in a sample of mexican children |
| topic | PAI-1 gene Polymorphisms Body adiposity Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2255553613000955 |
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