Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
Behçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.719235/full |
| _version_ | 1818734157327499264 |
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| author | Xiaomin Ma Xin Wang Guangbing Zheng Guiqin Tan Fangyu Zhou Wenwen Wei Dan Tian Hongsong Yu |
| author_facet | Xiaomin Ma Xin Wang Guangbing Zheng Guiqin Tan Fangyu Zhou Wenwen Wei Dan Tian Hongsong Yu |
| author_sort | Xiaomin Ma |
| collection | DOAJ |
| description | Behçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that genetics and environmental factors contribute to the increased development of BD. Recently, several studies have shown that external environmental factors can affect the process of epigenetic modification, and abnormalities of epigenetic factors have been confirmed to be involved in the occurrence of BD. At the same time, abnormalities of gut microbiota (GM) in the body, have also been confirmed to participate in the pathogenesis of BD by regulating the balance of Th17/Tregs. This article reviews the pathogenesis of BD and summarizes numerous clinical studies, focusing on the mechanism of GM and epigenetic factors impacting on BD, and providing new ideas for further elucidating the pathogenesis of BD. |
| first_indexed | 2024-12-18T00:00:54Z |
| format | Article |
| id | doaj.art-4c5605414bc04a16998508832043b046 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-18T00:00:54Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-4c5605414bc04a16998508832043b0462022-12-21T21:27:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.719235719235Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s DiseaseXiaomin MaXin WangGuangbing ZhengGuiqin TanFangyu ZhouWenwen WeiDan TianHongsong YuBehçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that genetics and environmental factors contribute to the increased development of BD. Recently, several studies have shown that external environmental factors can affect the process of epigenetic modification, and abnormalities of epigenetic factors have been confirmed to be involved in the occurrence of BD. At the same time, abnormalities of gut microbiota (GM) in the body, have also been confirmed to participate in the pathogenesis of BD by regulating the balance of Th17/Tregs. This article reviews the pathogenesis of BD and summarizes numerous clinical studies, focusing on the mechanism of GM and epigenetic factors impacting on BD, and providing new ideas for further elucidating the pathogenesis of BD.https://www.frontiersin.org/articles/10.3389/fcell.2021.719235/fullBehçet’s diseasegut microbiotaepigeneticsDNA methylationhistone modificationmicroRNA |
| spellingShingle | Xiaomin Ma Xin Wang Guangbing Zheng Guiqin Tan Fangyu Zhou Wenwen Wei Dan Tian Hongsong Yu Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease Frontiers in Cell and Developmental Biology Behçet’s disease gut microbiota epigenetics DNA methylation histone modification microRNA |
| title | Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease |
| title_full | Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease |
| title_fullStr | Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease |
| title_full_unstemmed | Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease |
| title_short | Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease |
| title_sort | critical role of gut microbiota and epigenetic factors in the pathogenesis of behcet s disease |
| topic | Behçet’s disease gut microbiota epigenetics DNA methylation histone modification microRNA |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.719235/full |
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