Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats
Dyslipidemia a chronic, metabolic syndrome characterized by elevated lipid profiles together with lipid peroxidation in individuals with atherosclerotic cardiovascular disease (CVD). Functional ingredients such as high phenolic content and potent antioxidant activity obtained from agricultural waste...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2023/17/bioconf_icfsb2023_02014.pdf |
| _version_ | 1797353179141111808 |
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| author | Liu Lijia Li Siwei Liang Lingling Mao Yan |
| author_facet | Liu Lijia Li Siwei Liang Lingling Mao Yan |
| author_sort | Liu Lijia |
| collection | DOAJ |
| description | Dyslipidemia a chronic, metabolic syndrome characterized by elevated lipid profiles together with lipid peroxidation in individuals with atherosclerotic cardiovascular disease (CVD). Functional ingredients such as high phenolic content and potent antioxidant activity obtained from agricultural waste by-products or waste are of great interest. However, the hypolipidemic effects of the waste mango (Mangifera indica L.) leaves (MLE) have not been investigated. Here, the specific lipid-lowering and potential hepatoprotective mechanisms by which the gavage administration of MLE affects lipid metabolism and liver steatosis in rats fed on a high-fat diet (HFD) were evaluated. In rats treated with high level of MLE, a persistent suppressive effect on liver weight and body weight gain was discovered after 28-day intervention. Furthermore, body lipid index and reduced inflammatory reaction and liver function parameters in HFD control rats were markedly ameliorated by supplementation with high doses of MLE. In addition, histological and histomorphometric analyses here demonstrated that fat accumulation changed in HFD supplemented hyperlipidaemia rats, but normalized in MLE treatment groups. Further real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) and western blot analyses were carried out to determine the mRNA and protein abundance of PPARα receptors and CYP7A1 in liver tissues of rats. These results indicate that MLE supplement have the promising lipid lowering effects in HFD-induced hyperlipidaemia rats based on positive ameliorations in the serum lipid profile and liver function parameters. |
| first_indexed | 2024-03-08T13:27:24Z |
| format | Article |
| id | doaj.art-4c5661c116874e3585d1939a09b24830 |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-03-08T13:27:24Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-4c5661c116874e3585d1939a09b248302024-01-17T14:52:32ZengEDP SciencesBIO Web of Conferences2117-44582023-01-01720201410.1051/bioconf/20237202014bioconf_icfsb2023_02014Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia ratsLiu Lijia0Li Siwei1Liang Lingling2Mao Yan3Faculty of Pharmacy, Guangxi University of Chinese MedicineGuangxi Key Laboratory of Efficacy Study on Chinese Materia MedicaGuangxi Key Laboratory of Efficacy Study on Chinese Materia MedicaFaculty of Pharmacy, Guangxi University of Chinese MedicineDyslipidemia a chronic, metabolic syndrome characterized by elevated lipid profiles together with lipid peroxidation in individuals with atherosclerotic cardiovascular disease (CVD). Functional ingredients such as high phenolic content and potent antioxidant activity obtained from agricultural waste by-products or waste are of great interest. However, the hypolipidemic effects of the waste mango (Mangifera indica L.) leaves (MLE) have not been investigated. Here, the specific lipid-lowering and potential hepatoprotective mechanisms by which the gavage administration of MLE affects lipid metabolism and liver steatosis in rats fed on a high-fat diet (HFD) were evaluated. In rats treated with high level of MLE, a persistent suppressive effect on liver weight and body weight gain was discovered after 28-day intervention. Furthermore, body lipid index and reduced inflammatory reaction and liver function parameters in HFD control rats were markedly ameliorated by supplementation with high doses of MLE. In addition, histological and histomorphometric analyses here demonstrated that fat accumulation changed in HFD supplemented hyperlipidaemia rats, but normalized in MLE treatment groups. Further real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) and western blot analyses were carried out to determine the mRNA and protein abundance of PPARα receptors and CYP7A1 in liver tissues of rats. These results indicate that MLE supplement have the promising lipid lowering effects in HFD-induced hyperlipidaemia rats based on positive ameliorations in the serum lipid profile and liver function parameters.https://www.bio-conferences.org/articles/bioconf/pdf/2023/17/bioconf_icfsb2023_02014.pdf |
| spellingShingle | Liu Lijia Li Siwei Liang Lingling Mao Yan Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats BIO Web of Conferences |
| title | Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats |
| title_full | Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats |
| title_fullStr | Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats |
| title_full_unstemmed | Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats |
| title_short | Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats |
| title_sort | effects of mangifera indica leaves improves blood lipids profile and biochemical indices in high fat diet induced hyperlipidaemia rats |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2023/17/bioconf_icfsb2023_02014.pdf |
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