Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
Abstract Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02876-2 |
| _version_ | 1811252178101207040 |
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| author | Li Zhou Huimin Zhu Xue Bai Jiagui Huang Yue Chen Jun Wen Xuemei Li Bowen Wu Yongjun Tan Mingfen Tian Jiangxia Ren Mengxia Li Qin Yang |
| author_facet | Li Zhou Huimin Zhu Xue Bai Jiagui Huang Yue Chen Jun Wen Xuemei Li Bowen Wu Yongjun Tan Mingfen Tian Jiangxia Ren Mengxia Li Qin Yang |
| author_sort | Li Zhou |
| collection | DOAJ |
| description | Abstract Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke. |
| first_indexed | 2024-04-12T16:30:58Z |
| format | Article |
| id | doaj.art-4c5757f16c6a40109abc52d098439a3f |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-12T16:30:58Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-4c5757f16c6a40109abc52d098439a3f2022-12-22T03:25:09ZengBMCStem Cell Research & Therapy1757-65122022-05-0113111510.1186/s13287-022-02876-2Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic strokeLi Zhou0Huimin Zhu1Xue Bai2Jiagui Huang3Yue Chen4Jun Wen5Xuemei Li6Bowen Wu7Yongjun Tan8Mingfen Tian9Jiangxia Ren10Mengxia Li11Qin Yang12Department of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke.https://doi.org/10.1186/s13287-022-02876-2Mesenchymal stem cellsIschemic strokeStem cell transplantationTherapeutic targetsRegenerative medicine |
| spellingShingle | Li Zhou Huimin Zhu Xue Bai Jiagui Huang Yue Chen Jun Wen Xuemei Li Bowen Wu Yongjun Tan Mingfen Tian Jiangxia Ren Mengxia Li Qin Yang Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke Stem Cell Research & Therapy Mesenchymal stem cells Ischemic stroke Stem cell transplantation Therapeutic targets Regenerative medicine |
| title | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
| title_full | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
| title_fullStr | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
| title_full_unstemmed | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
| title_short | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
| title_sort | potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
| topic | Mesenchymal stem cells Ischemic stroke Stem cell transplantation Therapeutic targets Regenerative medicine |
| url | https://doi.org/10.1186/s13287-022-02876-2 |
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