Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients
The primary control of dysmetabolic patients is extremely challenging worldwide, with inadequate dietary habits and sporadic physical activity among the key risk factors for metabolic syndrome onset. Nowadays, there is no exclusive treatment for this condition, and considering that preventive measur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/14/3142 |
| _version_ | 1797587932731670528 |
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| author | Sabrina Basciani Maurizio Nordio Simona Dinicola Vittorio Unfer Lucio Gnessi |
| author_facet | Sabrina Basciani Maurizio Nordio Simona Dinicola Vittorio Unfer Lucio Gnessi |
| author_sort | Sabrina Basciani |
| collection | DOAJ |
| description | The primary control of dysmetabolic patients is extremely challenging worldwide, with inadequate dietary habits and sporadic physical activity among the key risk factors for metabolic syndrome onset. Nowadays, there is no exclusive treatment for this condition, and considering that preventive measures usually fail, new therapeutic approaches need to be proposed and investigated. This present pilot study compared the effects of diet alone and in association with a combination of myo-inositol and <span style="font-variant: small-caps;">d</span>-chiro-inositol in their 40:1 ratio, α-lactalbumin, and <i>Gymnema sylvestre</i> on different metabolic parameters in obese dysmetabolic patients. To this purpose, 37 patients with BMI between 30 and 40 and fasting blood glucose between 100 and 125 mg/dL were divided into two groups: (<i>i</i>) the control group followed a hypocaloric Mediterranean diet, (<i>ii</i>) while the study group was also supplemented with a daily dosage of two sachets, each one containing 1950 mg myo-inositol, 50 mg <span style="font-variant: small-caps;">d</span>-chiro-inositol, 50 mg α-lactalbumin, and 250 mg <i>Gymnema Sylvestre</i>. After a 6-month treatment, all parameters improved in both groups. Nevertheless, the treated group experienced a greater improvement, especially concerning the variation from the baseline of HOMA index, triglycerides, BMI, body weight, and waist circumference. These findings support the supplementation with myo-inositol and <span style="font-variant: small-caps;">d</span>-chiro-inositol in the 40:1 ratio, α-lactalbumin, and <i>Gymnema sylvestre</i> as a therapeutical strategy to potentiate the beneficial effects induced via dietary programs in dysmetabolic patients. |
| first_indexed | 2024-03-11T00:45:53Z |
| format | Article |
| id | doaj.art-4c592bf22f874673a68a3bbd3a89d320 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:45:53Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4c592bf22f874673a68a3bbd3a89d3202023-11-18T20:47:48ZengMDPI AGNutrients2072-66432023-07-011514314210.3390/nu15143142Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic PatientsSabrina Basciani0Maurizio Nordio1Simona Dinicola2Vittorio Unfer3Lucio Gnessi4Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, ItalyThe Experts Group on Inositol in Basic and Clinical Research (EGOI), 00161 Rome, ItalyThe Experts Group on Inositol in Basic and Clinical Research (EGOI), 00161 Rome, ItalySection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, ItalyThe primary control of dysmetabolic patients is extremely challenging worldwide, with inadequate dietary habits and sporadic physical activity among the key risk factors for metabolic syndrome onset. Nowadays, there is no exclusive treatment for this condition, and considering that preventive measures usually fail, new therapeutic approaches need to be proposed and investigated. This present pilot study compared the effects of diet alone and in association with a combination of myo-inositol and <span style="font-variant: small-caps;">d</span>-chiro-inositol in their 40:1 ratio, α-lactalbumin, and <i>Gymnema sylvestre</i> on different metabolic parameters in obese dysmetabolic patients. To this purpose, 37 patients with BMI between 30 and 40 and fasting blood glucose between 100 and 125 mg/dL were divided into two groups: (<i>i</i>) the control group followed a hypocaloric Mediterranean diet, (<i>ii</i>) while the study group was also supplemented with a daily dosage of two sachets, each one containing 1950 mg myo-inositol, 50 mg <span style="font-variant: small-caps;">d</span>-chiro-inositol, 50 mg α-lactalbumin, and 250 mg <i>Gymnema Sylvestre</i>. After a 6-month treatment, all parameters improved in both groups. Nevertheless, the treated group experienced a greater improvement, especially concerning the variation from the baseline of HOMA index, triglycerides, BMI, body weight, and waist circumference. These findings support the supplementation with myo-inositol and <span style="font-variant: small-caps;">d</span>-chiro-inositol in the 40:1 ratio, α-lactalbumin, and <i>Gymnema sylvestre</i> as a therapeutical strategy to potentiate the beneficial effects induced via dietary programs in dysmetabolic patients.https://www.mdpi.com/2072-6643/15/14/3142myo-inositol<span style="font-variant: small-caps">d</span>-chiro-inositolinsulin-sensitizing effectα-lactalbumingut microbiotaintestinal inflammation |
| spellingShingle | Sabrina Basciani Maurizio Nordio Simona Dinicola Vittorio Unfer Lucio Gnessi Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients Nutrients myo-inositol <span style="font-variant: small-caps">d</span>-chiro-inositol insulin-sensitizing effect α-lactalbumin gut microbiota intestinal inflammation |
| title | Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients |
| title_full | Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients |
| title_fullStr | Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients |
| title_full_unstemmed | Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients |
| title_short | Diet Plus Inositols, α-Lactalbumin and <i>Gymnema sylvestre</i>: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients |
| title_sort | diet plus inositols α lactalbumin and i gymnema sylvestre i the successful combo to restore body weight and metabolic profile in obese and dysmetabolic patients |
| topic | myo-inositol <span style="font-variant: small-caps">d</span>-chiro-inositol insulin-sensitizing effect α-lactalbumin gut microbiota intestinal inflammation |
| url | https://www.mdpi.com/2072-6643/15/14/3142 |
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