Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men
We investigated the effects of dengue virus (DENV) on semen using samples collected 7, 15, 30, 60, and 90 days after symptom onset from 10 infected volunteers on Réunion Island. We assessed characteristics of semen and reproductive hormones and isolated motile spermatozoa from semen. We assayed sem...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2022-06-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/6/21-2317_article |
| _version_ | 1811247231745916928 |
|---|---|
| author | Joffrey Mons Dominique Mahé-Poiron Jean-Michel Mansuy Hélène Lheureux Delphine Nigon Nathalie Moinard Safouane Hamdi Christophe Pasquier Nathalie Dejucq-Rainsford Louis Bujan |
| author_facet | Joffrey Mons Dominique Mahé-Poiron Jean-Michel Mansuy Hélène Lheureux Delphine Nigon Nathalie Moinard Safouane Hamdi Christophe Pasquier Nathalie Dejucq-Rainsford Louis Bujan |
| author_sort | Joffrey Mons |
| collection | DOAJ |
| description |
We investigated the effects of dengue virus (DENV) on semen using samples collected 7, 15, 30, 60, and 90 days after symptom onset from 10 infected volunteers on Réunion Island. We assessed characteristics of semen and reproductive hormones and isolated motile spermatozoa from semen. We assayed semen for DENV using reverse transcription PCR and searched for DENV RNA by virus isolation in Vero E6 cell cultures. Four volunteers had >1 DENV RNA-positive semen samples; 2 volunteers had DENV RNA–positive semen at day 15 and 1 at day 30. No motile sperm were DENV positive. After exposure to positive semen, few Vero E6 cells stained positive for DENV antigens, indicating low levels of replicative virus. We found DENV had shorter duration in semen than in blood. These findings support the possibilities that DENV is sexually transmissible for a short period after acute dengue illness and that acute dengue induces reversible alterations in sperm.
|
| first_indexed | 2024-04-12T15:06:27Z |
| format | Article |
| id | doaj.art-4c5951bc595847459bdc1c3933b71c79 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T15:06:27Z |
| publishDate | 2022-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-4c5951bc595847459bdc1c3933b71c792022-12-22T03:27:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-06-012861146115310.3201/eid2806.212317Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of MenJoffrey MonsDominique Mahé-PoironJean-Michel MansuyHélène LheureuxDelphine NigonNathalie MoinardSafouane HamdiChristophe PasquierNathalie Dejucq-RainsfordLouis Bujan We investigated the effects of dengue virus (DENV) on semen using samples collected 7, 15, 30, 60, and 90 days after symptom onset from 10 infected volunteers on Réunion Island. We assessed characteristics of semen and reproductive hormones and isolated motile spermatozoa from semen. We assayed semen for DENV using reverse transcription PCR and searched for DENV RNA by virus isolation in Vero E6 cell cultures. Four volunteers had >1 DENV RNA-positive semen samples; 2 volunteers had DENV RNA–positive semen at day 15 and 1 at day 30. No motile sperm were DENV positive. After exposure to positive semen, few Vero E6 cells stained positive for DENV antigens, indicating low levels of replicative virus. We found DENV had shorter duration in semen than in blood. These findings support the possibilities that DENV is sexually transmissible for a short period after acute dengue illness and that acute dengue induces reversible alterations in sperm. https://wwwnc.cdc.gov/eid/article/28/6/21-2317_articledenguedengue virusDENVsexually transmitted infectionsfebrile illnessessperm |
| spellingShingle | Joffrey Mons Dominique Mahé-Poiron Jean-Michel Mansuy Hélène Lheureux Delphine Nigon Nathalie Moinard Safouane Hamdi Christophe Pasquier Nathalie Dejucq-Rainsford Louis Bujan Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men Emerging Infectious Diseases dengue dengue virus DENV sexually transmitted infections febrile illnesses sperm |
| title | Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men |
| title_full | Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men |
| title_fullStr | Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men |
| title_full_unstemmed | Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men |
| title_short | Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men |
| title_sort | effects of acute dengue infection on sperm and virus clearance in body fluids of men |
| topic | dengue dengue virus DENV sexually transmitted infections febrile illnesses sperm |
| url | https://wwwnc.cdc.gov/eid/article/28/6/21-2317_article |
| work_keys_str_mv | AT joffreymons effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT dominiquemahepoiron effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT jeanmichelmansuy effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT helenelheureux effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT delphinenigon effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT nathaliemoinard effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT safouanehamdi effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT christophepasquier effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT nathaliedejucqrainsford effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen AT louisbujan effectsofacutedengueinfectiononspermandvirusclearanceinbodyfluidsofmen |