Pharmacodynamics and Pharmacokinetics of HSK3486, a Novel 2,6-Disubstituted Phenol Derivative as a General Anesthetic

Pharmacodynamics and Pharmacokinetics of HSK3486, a Novel 2,6-Disubstituted Phenol Derivative as a General Anesthetic

Background: The purpose of this study was to characterize the novel sedative/hypnotic agent HSK3486, a 2,6-disubstituted alkylphenol analogue.Methods: The mechanism of action of HSK3486 was studied in competitive binding assays and whole-cell patch clamp assays. HSK3486 was administered by bolus int...

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Bibliographic Details
Main Authors: Juan Liao, Meiting Li, Chaoli Huang, Yan Yu, Yashu Chen, Jiaqi Gan, Jie Xiao, Guilin Xiang, Xizhi Ding, Rong Jiang, Peng Li, Mengchang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
anesthesia
GABA
sedation
pharmacokinetics
pharmacodynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.830791/full

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